Grantee Research Project Results

1999 Progress Report: Assessing Deposition of Ambient Particles in the Lung

EPA Grant Number: R827353C009
Subproject: this is subproject number 009 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Assessing Deposition of Ambient Particles in the Lung
Investigators: Tsuda, Akira
Current Investigators: Godleski, John J. , Tsuda, Akira
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 1999 through May 31, 2000
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air

Objective:

This project is one of three under Theme III: Biological Mechanisms and Dosimetry of our proposal. The main objective of this project is to use in situ continuous respiratory and total deposition measurements to develop a new regional deposition. This project was intended to address Particulate Matter Research Topic 6 identified by the National Research Council (NRC)-Dosimetry.

Progress Summary:

In this project, we have developed the capability to assess deposition of CAPs in awake dogs. These studies focus on using ambient particles to assess deposition in relationship to particle size, mass, and number. Hardware needed to be designed and implemented specifically for these studies. In addition, a number of modifications in existing equipment were needed to adapt these for use with the ambient particle concentrator. These have all been completed and tested. Deposition studies have been carried out on one pair of dogs. These went well and data analysis is in progress. We expect to present our initial findings in this area at the advisory council meeting.

Future Activities:

In the coming year, we expect to place considerable emphasis on our deposition studies. We expect to use the fine concentrator and define deposition of particles under a number of different atmospheric, seasonal, and weather pattern conditions. The relationship of mass, particle size, and compositional factors will be studied in relationship to deposition of ambient particles. In addition, we expect to be able to use our collected data in relationship to deposition models developed in our laboratory.

Journal Articles:

No journal articles submitted with this report: View all 4 publications for this subproject

Supplemental Keywords:

particulate matter, PM2.5, PM10, air pollutants, particulates, health effects, exposure, ambient particles, susceptibility, metals, public policy, biology, engineering, epidemiology, toxicology, environmental chemistry, monitoring., Health, RFA, Air, Scientific Discipline, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, particulate matter, Biology, genetic susceptability, Environmental Chemistry, Epidemiology, Environmental Microbiology, Molecular Biology/Genetics, indoor air, Toxicology, air toxics, epidemelogy, respiratory disease, air quality, health risks, Human Health Risk Assessment, indoor air quality, animal inhalation study, sensitive populations, health effects, human health, inhaled, biological mechanism , pulmonary disease, ambient monitoring, stratospheric ozone, respiratory, ambient air monitoring, indoor exposure, risk assessment, human exposure, pulmonary, genetic susceptibility, chemical exposure, particulate exposure, cardiopulmonary responses, dosimetry, monitoring, particulates, developmental effects, ambient particle health effects, exposure, COPD, PM, inhalation toxicology, inhaled particles, molecular epidemiology, ambient air, toxics, heart rate, air pollutants, air pollution, cardiovascular disease, human health risk, ambient air quality, human health effects, human susceptibility, cardiopulmonary, metals, particle exposure, cardiopulmonary response, interindividual variability, inhalation, ambient measurement methods

Relevant Websites:

http://www.hsph.harvard.edu/epacenter/homeframe.htm Exit

Progress and Final Reports:

Original Abstract

Main Center Abstract and Reports:

R827353 Health Effects Institute (2015 - 2020)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core

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