Grantee Research Project Results

Final Report: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage

EPA Grant Number: R838300
Title: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage
Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Kronmal, Richard , Barr, R. Graham , Burke, Gregory L. , Jacobs, David , Folsom, Aaron , Liu, Kiang J. , Sampson, Paul , Watson, Karol , Szpiro, Adam , Post, Wendy
Institution: University of Washington , Columbia University in the City of New York , Northwestern University , University of California - Los Angeles , Wake Forest University , University of Minnesota , The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2017 through August 31, 2021 (Extended to August 31, 2023)
Project Amount: $2,996,426
RFA: Long-term Exposure to Air Pollution and Development of Cardiovascular Disease (2016) RFA Text | Recipients Lists
Research Category: Air , Human Health , Airborne Particulate Matter Health Effects , Environmental Justice

Objective:

The aims for this project are unchanged from the original application. Our aims are: 1. To evaluate the relationship between individual-level long-term exposures to ambient air pollutants and the incidence of clinical CVD disease in the entire MESA Air cohort; 2. To characterize the relationships among individual-level long-term exposures to air pollutants and sub-clinical evidence of cardiovascular dysfunction and its sequelae, including progression of atherosclerosis, as determined by coronary artery calcium (CAC) measurements, cardiac structure and function by MRI and echocardiography, microvascular remodeling, and cerebrovascular consequences of atrial fibrillation; and 3. To quantify the impact of exposure measurement error (and role of increased model complexity and improved data quality) on health effect estimation and bias.

Summary/Accomplishments (Outputs/Outcomes):

The MESA Air Next Stage project was highly successful and productive with work achieved on many fronts including: events follow-up and ascertainment, air pollution model development and improvement, and epidemiological analyses. Follow-up calls for events ascertainment for MESA Air New Recruit participants and MESA Family participants recruited into MESA Air began in year 1 and concluded in year 4. Significant work has been done to adjudicate identified events from these follow-up calls, prioritizing older events first, with all events through 2019 adjudicated and available to MESA Air Next Stage researchers. In addition to the events surveillance and adjudication work, we have made considerable progress on novel modeling approaches including extending all of our city-specific models through mid-2018. A high-resolution spatiotemporal daily carbon monoxide (CO) model developed for Baltimore using both regulatory measurements at agency monitoring sites and measurements from low-cost gas monitors deployed by our team has been published in Environmental Health Perspectives. We have improved the predictive performance of and extended our historical PM2.5 model resulting in improved predictions for the period between 1980 and 2019. Our efforts to more accurately model fine near-roadway concentration gradients for traffic-related air pollutants continued; we incorporated RLINE estimates as a spatial covariate in LA NO2 and Chicago NOx models and found that integrating RLINE improved model performance. We have also developed national biweekly models for four PM2.5 species. We have continued to make considerable updates to our database and modeling infrastructure that streamline model development and compiling data for health analyses. On the health analysis side, we finalized the primary results of the cardiovascular events analysis and are in the process of finalizing a manuscript for that key health analysis, as well as an analyses of the risk of air pollution on development of heart failure and key sub-types.

Conclusions:

We plan to submit results in the next several months investigating the impact of exposure to PM2.5 on cognitive decline using our improved historical PM2.5 model, which has improved performance in the period before widespread PM2.5 monitoring was available. We have leveraged our MESA Air exposures models to publish work investigating the impact of air pollution on child behavior, child blood pressure, dementia, depression, and biomarkers of inflammation. Many additional epidemiological analyses are underway, and the data generated by MESA Air on subclinical cardiovascular disease have become a key resource used by dozens of investigators. We have continued our measurement error work by investigating the impact of study design on health analyses. Finally, we are also continuing our commitment to data sharing by releasing additional de-identified data through NIH/NHLBI’s BioLINCC.

Journal Articles on this Report : 3 Displayed | Download in RIS Format

Publications Views
Other project views:	All 62 publications	56 publications in selected types	All 56 journal articles

Publications
Type	Citation	Project	Document Sources
Journal Article	Dzaye O, Razavi A, Dardari Z, Nasir K, Matsushia K, Mok Y, Santilli F, Cobo A, Johri A, Albrecht G, Blaha M. Carotid Ultrasound-Based Plaque Score for the Allocation of Aspirin for the Primary Prevention of Cardiovascular Disease Events:The Multi-Ethnic Study of Atherosclerosis and the Atherosclerosis Risk in Communities Study. JOURNAL OF THE AMERICAN HEART ASSOCIATION 2024;13(12).	R838300 (Final) R831697 (Final)	Full-text from PubMed Full-text: JAHA - Full Text HTML Exit
Journal Article	Higbee D, Liri A, Hamilton F, Granell R, Wyss A, London S, Bartz T, Gharib S, Cho M, Wan E, Silverman E, Crapo J, Lominchar J, Hansen T, Grarup N, Dantoft T, Karhus L, Linneberg A, O'Connor G, Dupis J, Xu H, DeVries M, Hu X, Rich S, Barr R, Manichaikul A, Wijnat S, Brusselle G, Lahousse L, Li X, Cordero A, Obeidat M, Sin D, Harris S, Redmond P, Taylor A, Cox S, Williams A, Shrine N, John C, Guyatt A, Hall I, Smith G, Tobin M, Dodd J. Genome-wide association study of preserved ratio impaired spirometry (PRISm). EUROPEAN RESPIRATORY JOURNAL 2024;63(1):2300337.	R838300 (Final) R831697 (Final)	Full-text from PubMed Abstract from PubMed Full-text: ERS Publications - Full Text HTML Exit
Journal Article	Ni Y, Sullivan A, Szpiro A, Peng J, Loftus C, Hazelhurst M, Sherris A, Wallace E, Murphy L, Nguyen R, Swan S, Sathysnarayana S, Barrett E, Mason W, Bush N, Karr C, Lewinn K. Ambient Air Pollution Exposures and Child Executive Function: A US Multicohort Study. EPIDEMIOLOGY 2024;93335(5):676-688	R838300 (Final) R831697 (Final) R834796 (Final)	Full-text from PubMed Full-text: Epidemiology - Full Text HTML Exit

Supplemental Keywords:

Ambient air, human health, particulates, epidemiology, ozone, traffic-related air pollution, exposure modeling, spatio-temporal

Relevant Websites:

Mesa Air Exit

Progress and Final Reports:

Original Abstract

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.