Grantee Research Project Results
2019 Progress Report: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage
EPA Grant Number: R838300Title: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage
Investigators: Kaufman, Joel D. , Kronmal, Richard , Barr, R. Graham , Burke, Gregory L. , Sampson, Paul , Watson, Karol , Szpiro, Adam , Post, Wendy , Pankow, James F. , Jacobs, David , Allen, Norrina
Current Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Kronmal, Richard , Barr, R. Graham , Burke, Gregory L. , Jacobs, David , Folsom, Aaron , Liu, Kiang J. , Sampson, Paul , Watson, Karol , Szpiro, Adam , Post, Wendy
Institution: University of Washington , Columbia University in the City of New York , Northwestern University , University of California - Los Angeles , Wake Forest University , University of Minnesota , The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2017 through August 31, 2021 (Extended to August 31, 2023)
Project Period Covered by this Report: September 1, 2018 through August 31,2019
Project Amount: $2,996,426
RFA: Long-term Exposure to Air Pollution and Development of Cardiovascular Disease (2016) RFA Text | Recipients Lists
Research Category: Air , Human Health , Airborne Particulate Matter Health Effects , Environmental Justice
Objective:
The aims for this project are unchanged from the original application. As we stated in our proposal, our aims are: 1. To evaluate the relationship between individual-level long-term exposures to ambient air pollutants and the incidence of clinical CVD disease in the entire MESA Air cohort; 2. To characterize the relationships among individual-level long-term exposures to air pollutants and sub-clinical evidence of cardiovascular dysfunction and its sequelae, including progression of atherosclerosis, as determined by coronary artery calcium (CAC) measurements, cardiac structure and function by MRI and echocardiography, microvascular remodeling, and cerebrovascular consequences of atrial fibrillation; and 3. To quantify the impact of exposure measurement error (and role of increased model complexity and improved data quality) on health effect estimation and bias.
Progress Summary:
Progress in year 2 was as anticipated with continued events follow-up, air pollution modeling updates, and progress on health analyses. In year 2, follow-up calls for events ascertainment for MESA Air New Recruit participants and MESA Family participants recruited into MESA Air have continued at all six MESA field centers. Significant work has been done to adjudicate identified events from these follow-up calls, prioritizing older events first. Additional work conducted during this project period included extension (in time through the end of 2018) of the MESA Air exposure models. We have also made updates to our database and modeling infrastructure, which significantly boosted computational performance of our models and provide measures to enhance efficiency, reliability, and reproducibility of our methods. The events analysis is underway but is pending receipt of additional data from the MESA Coordinating Center.
Future Activities:
Throughout the next year, events ascertainment and adjudication in all six MESA cities will continue. The University of Washington team will continue to work on improvements to our exposure model with a focus on improving near-road exposure prediction. Our team will continue to work on health analyses, including the events analysis and an analysis of the relationship between exposure to air pollution and left ventricular structure and function. We will also continue to address the data sharing aspects of the project.
Journal Articles on this Report : 16 Displayed | Download in RIS Format
Other project views: | All 60 publications | 54 publications in selected types | All 54 journal articles |
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Hayes RB, Lim C, Zhang Y, Cromar K, Shao Y, Reynolds HR, Silverman DT, Jones RR, Park Y, Jerrett M, Ahn J. PM2.5 air pollution and cause-specific cardiovascular disease mortality. International Journal of Epidemiology 2019. . |
R838300 (2019) R838300 (2020) |
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Shea S, Stein JH, Jorgensen NW, McClelland RL, Tascau L, Shrager S, Heinecke JW, Yvan-Charvet L, Tall AR. Cholesterol mass efflux capacity, incident cardiovascular disease, and progression of carotid plaque:the Multi-Ethnic Study of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 2019;39(1):89-96. |
R838300 (2019) R838300 (2020) R831697 (Final) |
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Aaron CP, Schwartz JE, Hoffman EA, Angelini E, Austin JH, Cushman M, Jacobs Jr DR, Kaufman JD, Laine A, Smith LJ, Yang J. A longitudinal cohort study of aspirin use and progression of emphysema-like lung characteristics on CT imaging:the MESA Lung Study. Chest 2018;154(1):41-50. |
R838300 (2019) R838300 (2020) |
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Oelsner EC, Balte PP, Cassano PA, Couper D, Enright PL, Folsom AR, Hankinson J, Jacobs Jr DR, Kalhan R, Kaplan R, Kronmal R. Harmonization of respiratory data from 9 US population-based cohorts:the NHLBI pooled cohorts study. American Journal of Epidemiology 2018;187(11):2265-2278. |
R838300 (2019) R838300 (2020) |
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Aroner SA, Koch M, Mukamal KJ, Furtado JD, Stein JH, Tattersall MC, McClelland RL, Jensen MK. High‐density lipoprotein subspecies defined by Apolipoprotein C‐III and subclinical atherosclerosis measures:MESA (the multi‐ethnic study of atherosclerosis). Journal of the American Heart Association 2018;7(6):e007824. |
R838300 (2019) R838300 (2020) |
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Oelsner EC, Smith BM, Hoffman EA, Kalhan R, Donohue KM, Kaufman JD, Nguyen JN, Manichaikul AW, Rotter JI, Michos ED, Jacobs Jr DR. Prognostic significance of large airway dimensions on computed tomography in the general population. The multi-ethnic study of atherosclerosis (MESA) lung study. Annals of the American Thoracic Society 2018;15(6):718-727. |
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Wang M, Aaron CP, Madrigano J, Hoffman EA, Angelini E, Yang J, Laine A, Vetterli TM, Kinney PL, Sampson PD, Sheppard LE. Association between long-term exposure to ambient air pollution and change in quantitatively assessed emphysema and lung function. JAMA 2019;322(6):546-556. |
R838300 (2019) R838300 (2020) R831697 (Final) R834798 (Final) |
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Wang M, Sampson PD, Sheppard LE, Stein JH, Vedal S, Kaufman JD. Long-term exposure to ambient ozone and progression of subclinical arterial disease:the multi-ethnic study of atherosclerosis and air pollution. Environmental Health Perspectives 2019;127(5):057001. |
R838300 (2019) R838300 (2020) R834796 (Final) |
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Oelsner EC, Ortega VE, Smith BM, Nguyen JN, Manichaikul AW, Hoffman EA, Guo X, Taylor KD, Woodruff PG, Couper DJ, Hansel NN. A genetic risk score associated with chronic obstructive pulmonary disease susceptibility and lung structure on computed tomography. American Journal of Respiratory and Critical Care Medicine 2019;200(6):721-731. |
R838300 (2019) R838300 (2020) |
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Aaron CP, Hoffman EA, Kawut SM, Austin JH, Budoff M, Michos ED, Stukovsky KH, Sack C, Szpiro AA, Watson KD, Kaufman JD. Ambient air pollution and pulmonary vascular volume on computed tomography:the MESA Air Pollution and Lung cohort studies. European Respiratory Journal 2019;53(6):1802116. |
R838300 (2019) R838300 (2020) |
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Quraishi SM, Lin PC, Richter KS, Hinckley MD, Yee B, Neal-Perry G, Sheppard L, Kaufman JD, Hajat A. Ambient air pollution exposure and fecundability in women undergoing in vitro fertilization. Environmental Epidemiology 2019;3(1):e036. |
R838300 (2019) R838300 (2020) |
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Mitchell CC, Korcarz CE, Gepner AD, Nye R, Young RL, Matsuzaki M, Post WS, Kaufman JD, McClelland RL, Stein JH. Carotid artery echolucency, texture features, and incident cardiovascular disease events:The MESA Study. Journal of the American Heart Association 2019;8(3):e010875. |
R838300 (2019) R838300 (2020) |
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Hajat A, Diez Roux AV, Castro-Diehl C, Cosselman K, Golden SH, Hazlehurst MF, Szpiro A, Vedal S, Kaufman JD. The association between long-term air pollution and urinary catecholamines:evidence from the multi-ethnic study of atherosclerosis. Environmental Health Perspectives 2019;127(5):057007. |
R838300 (2019) R838300 (2020) |
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Billings ME, Gold D, Szpiro A, Aaron CP, Jorgensen N, Gassett A, Leary PJ, Kaufman JD, Redline SR. The association of ambient air pollution with sleep apnea:the multi-ethnic study of atherosclerosis. Annals of the American Thoracic Society 2019;16(3):363-370. |
R838300 (2019) R838300 (2020) |
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Zusman M, Schumacher CS, Gassett AJ, Spalt EW, Austin E, Larson TV, Carvlin G, Seto E, Kaufman JD, Sheppard L. Calibration of low-cost particulate matter sensors:model development for a multi-city epidemiological study. Environment International 2020;134:105329.. |
R838300 (2019) R838300 (2020) R831697 (Final) |
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Oelsner EC, Balte PP, Grams ME, Cassano PA, Jacobs DR, Barr RG, Burkart KM, Kalhan R, Kronmal R, Loehr LR, O’Connor GT. Albuminuria, lung function decline, and risk of incident chronic obstructive pulmonary disease. The NHLBI Pooled Cohorts Study. American Journal of Respiratory and Critical Care Medicine. 2019;199(3):321-332. |
R838300 (2019) R838300 (2020) |
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Supplemental Keywords:
Ambient air, human health, particulates, epidemiology, ozone, traffic-related air pollution, exposure modeling, spatio-temporalRelevant Websites:
Multi-Ethnic Study of Atherosclerosis and Air Pollution Site Exit
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2022 Progress Report
- 2021 Progress Report
- 2020 Progress Report
- 2018 Progress Report
- Original Abstract
54 journal articles for this project