Grantee Research Project Results

2018 Progress Report: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage

EPA Grant Number: R838300
Title: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage
Investigators: Kaufman, Joel D. , Barr, R. Graham , Burke, Gregory L. , Folsom, Aaron , Szpiro, Adam , Jacobs, David , Watson, Karol , Allen, Norrina , Sampson, Paul , Kronmal, Richard , Post, Wendy
Current Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Kronmal, Richard , Barr, R. Graham , Burke, Gregory L. , Jacobs, David , Folsom, Aaron , Liu, Kiang J. , Sampson, Paul , Watson, Karol , Szpiro, Adam , Post, Wendy
Institution: University of Washington , Northwestern University , University of California - Los Angeles , The Johns Hopkins University , Wake Forest University , University of Minnesota , Columbia University in the City of New York
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , University of California - Los Angeles , Wake Forest University , University of Minnesota , The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2017 through August 31, 2021 (Extended to August 31, 2023)
Project Period Covered by this Report: September 1, 2017 through August 31,2018
Project Amount: $2,996,426
RFA: Long-term Exposure to Air Pollution and Development of Cardiovascular Disease (2016) RFA Text | Recipients Lists
Research Category: Air , Human Health , Airborne Particulate Matter Health Effects , Environmental Justice

Objective:

As stated in the proposal, the aims are as follows:

Evaluate the relationship between individual-level long-term exposures to ambient air pollutants and the incidence of clinical cardiovascular disease in the entire Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) cohort.
Characterize the relationships among individual-level long-term exposures to air pollutants and sub-clinical evidence of cardiovascular dysfunction and its sequelae, including progression of atherosclerosis, as determined by coronary artery calcium measurements, cardiac structure and function by MRI and echocardiography, microvascular remodeling, and cerebrovascular consequences of atrial fibrillation.
Quantify the impact of exposure measurement error (and role of increased model complexity and improved data quality) on health effect estimation and bias.

Progress Summary:

The primary accomplishment for Year 1 was to set up and start follow-up calls for events ascertainment for MESA Air New Recruit participants and MESA Family participants recruited into MESA Air at all six MESA field centers. Additional work conducted during this project period included refinement of exposure covariates (e.g., bus routes), improvements to the NO₂ model and planning for the ozone model.

Future Activities:

In Year 2, the primary activity will be continued events ascertainment in all six MESA cities and adjudication. The University of Washington team will continue to make improvements to exposure models and work on events analysis.

Journal Articles on this Report : 6 Displayed | Download in RIS Format

Publications Views
Other project views:	All 62 publications	56 publications in selected types	All 56 journal articles

Publications
Type	Citation	Project	Document Sources
Journal Article	Adar SD, Chen YH, D'Souza JC, O'Neill MS, Szpiro AA, Auchincloss AH, Park SK, Daviglus ML, Diez Roux AV, Kaufman JD. Longitudinal analysis of long-term air pollution levels and blood pressure:a cautionary tale from the Multi-Ethnic Study of Atherosclerosis. Environmental Health Perspectives 2018;126(10):107003 (11 pp.).	R838300 (2018) R838300 (2020)	Full-text from PubMed Abstract from PubMed Full-text: EHP - Full Text HTML Abstract: EHP-Abstract and Full Text HTML Other: EHP-Full Text PDF
Journal Article	Gronlund CJ, Sheppard L, Adar SD, O'Neill MS, Auchincloss A, Madrigano J, Kaufman J, Diez Roux AV. Vulnerability to the cardiovascular effects of ambient heat in six US cities:Results from the Multi-Ethnic Study of Atherosclerosis (MESA). Epidemiology 2018;29(6):756-764.	R838300 (2018) R838300 (2020)	Abstract from PubMed Abstract: Epidemiology-Abstract Exit Other: ResearchGate-Abstract Exit
Journal Article	Keller JP, Larson TV, Austin E, Barr RG, Sheppard L, Vedal S, Kaufman JD, Szpiro AA. Pollutant composition modification of the effect of air pollution on progression of coronary artery calcium:the Multi-Ethnic Study of Atherosclerosis. Environmental Epidemiology 2018;2:e024.	R838300 (2018) R838300 (2020) R834796 (Final) R834796C005 (Final)	Full-text from PubMed Abstract from PubMed Full-text: Environmental Epidemiology-Full Text PDF Exit Other: Environmental Epidemiology - Full Text EPUB Exit
Journal Article	Manichaikul A, Wang XQ, Li L, Erdmann J, Lettre G, Bis JC, Waterworth D, Cushman M, Jenny NS, Post WS, Palmas W, Tsai MY, Wallentin L, White H, Schunkert H, O'Donnell CJ, Herrington DM, Rich SS, O'Donoghue ML, Rodriguez A. Lp-PLA₂ , scavenger receptor class B type I gene (SCARB1 ) rs10846744 variant, and cardiovascular disease. PloS One 2018;13(10):e0204352.	R838300 (2018) R838300 (2020)	Full-text from PubMed Abstract from PubMed Associated PubMed link Full-text: PLoS One-Full Text HTML Exit Abstract: PLoS One-Abstract Exit Other: PLoS One-Full Text PDF Exit
Journal Article	Miller KA, Spalt EW, Gassett AJ, Curl CL, Larson TV, Avol E, Allen RW, Vedal S, Szpiro AA, Kaufman JD. Estimating ambient-origin PM_2.5 exposure for epidemiology: observations, prediction, and validation using personal sampling in the Multi-Ethnic Study of Atherosclerosis. Journal of Exposure Science and Environmental Epidemiology 2019;29(2):227-237.	R838300 (2018) R838300 (2020) R831697 (Final) R834796 (Final)	Full-text from PubMed Abstract from PubMed Associated PubMed link Full-text: Nature - Full Text HTML Exit
Journal Article	Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpelainen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R, Liu Y, Manning AK, Rankinen T, Smith AV, et al. A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure. The American Journal of Human Genetics 2018;102(3):375-400.	R838300 (2018) R838300 (2020)	Full-text from PubMed Abstract from PubMed Associated PubMed link Full-text: ScienceDirect-Full Text HTML Exit Abstract: ScienceDirect-Abstract Exit Other: ScienceDirect-Full Text PDF Exit

Supplemental Keywords:

Ambient air, human health, particulates, epidemiology, ozone, traffic-related air pollution, exposure modeling, spatio-temporal

Relevant Websites:

Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) Exit

Progress and Final Reports:

Original Abstract

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.