Grantee Research Project Results
Health Effects Institute (2015-2020): A Partnership for Credible and Relevant Science on the Health Effects of Air Pollution
EPA Grant Number: R835902Center: Health Effects Institute (Prior to 2000)
Center Director: Greenbaum, Daniel S.
Title: Health Effects Institute (2015-2020): A Partnership for Credible and Relevant Science on the Health Effects of Air Pollution
Investigators: Greenbaum, Daniel S. , Shaikh, Rashid , O’Keefe, Robert
Current Investigators: Greenbaum, Daniel S. , O’Keefe, Robert , Shaikh, Rashid
Institution: Health Effects Institute
EPA Project Officer: Keating, Terry
Project Period: April 1, 2015 through March 31, 2020
Project Amount: $25,000,000
RFA: Health Effects Institute (2015) RFA Text | Recipients Lists
Research Category: Air
Objective:
HEI has built its application based on significant progress under the HEI Application/Strategic Plan for 2010 – 2015. This Application is built around the overarching theme: Informing Air Quality and Climate Technology Decisions for 2015 – 2020…and Beyond.” This theme is integrated into four core program elements: the Continuing Challenges of Multipollutant Science; Accountability and Transparency; Assessing Emerging Fuels and Technologies; and Global Health Science. In each of these areas, HEI has described detailed plans for its research and other scientific activities, including: (1) Completing and communicating the results of key studies on ozone and cardiovascular effects, traffic exposure, diesel, accountability, and other important topics; (2) Launching major new research initiatives including, among others: examining potential effects at lower levels of exposure; new targeted studies of the health effects of traffic exposure; the next generation of accountability studies of major air quality actions; and, with additional funds, new source-specific assessment of air pollution health impacts in developing countries; (3) Targeted Scientific Review and Synthesis, including an updated review of the effects of exposure to traffic, and development of systematic toxicity testing protocols, and workshops on key issues pertaining to emerging fuels and technologies; and (4) Pursuing, across our work, important cross-cutting issues in all of our efforts, including innovation and testing of statistical analysis and modeling approaches; at-risk populations; climate change; enhanced exposure assessment; new biologic techniques; and new health endpoints. The HEI Application also includes flexibility to anticipate and act on the unanticipated events that may call for HEI’s expertise during the project period. The outcomes of the proposed research and review activities are anticipated to respond to several key needs in frontier areas of environmental sciences and decision making, including multi-pollutant science, accountability, new fuels and technologies, and global health.
Journal Articles: 21 Displayed | Download in RIS Format
| Other center views: | All 57 publications | 57 publications in selected types | All 21 journal articles |
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Arjomandi M, Balmes J, Frampton M, Bromberg P, Rich D, Stark P, Alexis N, Costantini M, Hollenbeck-Pringle D, Dagincourt N, Hazucha M. RespiratoryResponses to Ozone Exposure MOSES (The MultiR Ozone Study in Older Subjects). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2018;197(10):1319-1927. |
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Balmes J, Arjomandi M, Bromberg P, Constantini M, Dagincourt N, Hazucha M, Hollenbeck-Pringle D, Stark P, Frampton M. Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis:The Multicenter Ozone Study in oldEr Subjects (MOSES). PLOS ONE 2018;14(9):e0222601. |
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Bouma F, Janssen N, Wessling J, van Ratingen S, Strak M, Kerckhoffs J, Gehring U, Hendricx W, de Hoogh K, Vermeulen R, Hoek G. Long-term exposure to ultrafine particles and natural and cause-specific mortality. ENVIRONMENTAL INTERNATIONAL 2023;175(107960). |
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Chau K, Franklin M, Gauderman W. Satellite-Derived PM2.5 Composition and Its Differential Effect on Children Lung Function. REMOTE SENSING 2020;12(6). |
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De MOira A, Pearce N, Pedersen M, Andersen A. The influence of early-life animal exposure on the risk of childhood atopic dermatitis, asthma and allergic rhinoconjunctivitis: findings from the Danish National Birth Cohort. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 2023;dyad040 |
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Fallah-Shorshani M, Yin X, McConnell R, Fruin S, Franklin M. Estimating traffic noise over a large urban area: An evaluation of methods. ENVIRONMENTAL INTERNATIONAL 2022;170(107583) |
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Fang T, Lakey P, Weber R, Shiraiwa M. Oxidative Potential of Particulate Matter and Generation of Reactive Oxygen Species in Epithelial Lining Fluid. ENVIRONMENAL SCIENCE TECHNOLOGY 2019;53(21):12784-12792. |
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Fang T, Huang Y, Wei J, Monterrosa J, Lakey P, Kleinman M, Digman M, Shiraiwa M. Superoxide Release by Macrophages through NADPH Oxidase Activation Dominating Chemistry by Isoprene Secondary Organic Aerosols and Quinones to Cause Oxidative Damage on Membranes. ENVIRONMENTAL SCIENCE AND TECHNOLOGY 2022;56(23):17029-17038 |
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Franklin M, Yin X, McConnell R, Fruin S. Association of the Built Environment With Childhood Psychosocial Stress. ENVIRONMENTAL HEALTH 2020;3(10):17634. |
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Groot J, Keller A, Pedersen M, Sisgaard T, Loft S, Andersen A. Indoor home environments of Danish children and the socioeconomic position and health of their parents:A descriptive study. Environmental International 2022;160. |
R835902 (Final) CR839981 (Final) |
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Mila C, Ballester J, Basagana X, Nieuwenhuigsen M, Tonne C. Estimating daily air temperature and pollution in Catalonia: A comprehensive spatiotemporal modelling of multiple exposures. ENVIRONMENTAL POLLUTION 2023;337(122501) |
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Pedersen M. Is ambient air pollution a Risk factor for fecundity?. EPIDEMIOLOGY 2022;36(1):68-69. |
R835902 (Final) |
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Pedersen M, Liu S, Zhang J, Zndersen Z, Brandt J, Butdz-Jorgensen E, Bonnelykke K, Frohn L, Andersen A, Ketzel M, Khan J, Stayner L, Brunekreef B, Loft S. Early-Life Exposure to Ambient Air Pollution from Multiple Sources and Asthma Incidence in Children: A Nationwide Birth Cohort Study from Denmark. ENVIRONMENTAL HEALTH PERSPECTIVES 2023;131(5):057003 |
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Peters S, Bouma F, Hoek G, Janssen N, Vermeulen R. Air pollution exposure and mortality from neurodegenerative diseases in the Netherlands: a population-based cohort study. Environmental Research 2024;259:119552. |
R835902 (Final) CR839981 (Final) |
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Rich D, Balmes J, Frampton M, Zareba W, Stark P, Arjomandi M, Hazucha M, Costantini M, Ganz P, Hollenbeck-Pringle D, Dagincourt N, Bromberg P. Cardiovascular function and ozone exposure:The Multicenter Ozone Study in older Subjects (MOSES). ENVIRONMENTAL INTERNATIONAL 2018;119:193-202. |
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Ripley S, Minet L, Zalzal J, Pollitt K, Gao D, Lakay P, Shiraiwa M, Maher B, Hatzopoulou M, Weicherenthal S. Predicting Spatial Variations in Multiple Measures of PM2.5 Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada. ENVIRONMENTAL SCIENCE TECHNOLOGY 2022;56(11):7256-7265. |
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Thacher J, Poulsen A, Hvidfeldt U, Brandt J, Christensen J, Khan J, Gregor M, Sorensen M. Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark. ENVIRONMENAL RESEARCH 2022;211. |
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Yin X, Fallah-Shorshani M, McConnell R, Fruin S, Franklin M. Predicting Fine Spatial Scale Traffic Noise Using Mobile Measurements and Machine Learning. ENVIRONMENTAL SCIENCE TECHNOLOGY 2020;54(20):12860-12869. |
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Yin X, Franklin M, Fallah-Shorshani M, Shafer M, McConnell R, Fruin R. Exposure models for particulate matter elemental concentrations in Southern California. ENVIRONMENT INTERNATIONAL 2022;165(107427). |
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Zhang J, Lim Y, So R, Jorgensen J, Mortensen L, Napolitano G, Cole-Hunter T, Loft S, Bhatt S, Hoek G, Brunekreef B, Westdorp R, Ketzel M, Brandt J, Lange T, Kilsen-Fisher T, Andersen Z. Long-term exposure to air pollution and risk of SARS-CoV-2 infection and COVID-19 hospitalisation or death:Danish nationwide cohort study. EUROPEAN RESPIRATORY JOURNAL 2023;62(1):2300280. |
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Zhang Z, Weichenthal S, Kwong J, Burnett R, Hatzopoulou M, Jerrett M, van Donklaar A, Bai L, Martin R, Copes R, Lakey P, Shirwiwa M, Cheng H. Long-term exposure to iron and copper in fine particulate air pollution and their combined impact on reactive oxygen species concentration in lung fluid:a population-based cohort study of cardiovascular disease incidence and mortality in Toronto, Canada. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 2021;50(2):589-601. |
R835902 (Final) |
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Supplemental Keywords:
Health effects; human health; air pollution; mobile sources; exposure assessment; sensitive populations; susceptibility; dose response; emissions; transportation; Bayesian; environmental chemistry; modeling; monitoring; statistical methods; epidemiology; Ozone, particulate matter; VOCs;Progress and Final Reports:
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.