Main Title |
Empirical Comparisons of Carcinogen Potencies Across Species and Their Bearing on Appropriate Scaling of Doses for Risk Assessment. |
Author |
Rhomberg, L. ;
|
CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
Publisher |
c1994 |
Year Published |
1994 |
Report Number |
EPA/600/A-94/080 ;OHEA-C-494; |
Stock Number |
PB94-169935 |
Additional Subjects |
Carcinogens ;
Toxicology ;
Species diversity ;
Dose-response relationships ;
Body weight ;
Mammals ;
Humans ;
Risk assessment ;
Potable water ;
Water pollutants ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB94-169935 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
21p |
Abstract |
The chapter is adapted from the recent proposal by the Interagency Pharmacokinetics Group (IPG) advocating the adoption by the participating Federal regulatory agencies of a unified method of scaling daily administered amount of a carcinogenic agent in proportion to the 3/4 power of body weight. The dose-scaling approach was proposed as a default assumption, to be used when case-specific data are inadequate, to achieve presumed equal lifetime cancer risks in different mammalian species following lifetime exposure. In this chapter, the empirical investigations of how carcinogen potencies vary among species are reviewed and the implications for choice of a general risk assessment methodology for carcinogen dose scaling are discussed. The empirical data on comparative carcinogenic potencies in different species support the general practice of scaling rodent potencies to humans, and show that, on average, current methods perform rather well. The data are not of sufficient resolution, however, to distinguish between surface area and body weight dose scaling. |
Supplementary Notes |
Pub. in Water Contamination and Health, Integration of Exposure Assessment, Toxicology, and Risk Assessment, p425-441 1994. See also PB87-228557 and PB87-228565. |
NTIS Title Notes |
Book chapter. |
Title Annotations |
Reprint: Empirical Comparisons of Carcinogen Potencies Across Species and Their Bearing on Appropriate Scaling of Doses for Risk Assessment. |
Category Codes |
57Y; 57U; 68D; 68G |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/21 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
418226459 |
Origin |
NTIS |
Type |
CAT |