||Assessment of Teratogenic Potential of Trichlorofon in Mice and Rats (Journal Version).
Courtney, K. D. ;
Andrews, J. E. ;
Springer, J. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Food and Drug Administration, Washington, DC. Center for Food Safety and Applied Nutrition.
Laboratory animals ;
Lethal dosage ;
Phosphorus organic compounds ;
Phosphoric acid/trichloro-hydroxyethyl-(dimethyl ester)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Trichlorofon was evaluated for its teratogenic potential in the CD-1 mouse at doses of 200, 300, or 400 mg/kg/day administered by gavage on days 7-16 of gestation. In the CD-1 mouse, TCF was teratogenic, fetotoxic and lethal at the two highest dose levels which were also maternally lethal. At the lowest dose level which was not maternally lethal, there was a significant decrease in the number of calcified centers in the forepaws and hindpaws indicating fetotoxicity and a delay in maturation. TCF was administered at doses of 50, 100, or 200 mg/kg/day to CD rats by gavage on gestational days 7-19 (study I) or 8-20 (study II). In both study I and II, the highest dose level was maternally lethal. In study I, TCF was teratogenic with a shift in rib profile. In study II, TCF was teratogenic with an increased incidence in malformations of the urinary system. Additionally, TCF was fetotoxic with reduced ossification of the skulls.
||Pub. in Jnl. of Environmental Science Health, vB21 n3 p207-227 1986. Prepared in cooperation with Food and Drug Administration, Washington, DC. Center for Food Safety and Applied Nutrition.
|NTIS Title Notes
||Reprint: Assessment of Teratogenic Potential of Trichlorofon in Mice and Rats (Journal Version).
||57P; 57Y; 68E; 68G
||PC A03/MF A01