||Multiple-Endpoint Mutagenesis with Chinese Hamster Ovary (CHO) Cells: Evaluation with Eight Carcinogenic and Non-Carcinogenic Compounds.
Hsie, A. W. ;
San Sebastian, J. R. ;
Perdue, S. W. ;
Schenley, R. L. ;
Winters, M. D. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Texas Univ. Medical Branch at Galveston. Dept. of Preventive Medicine and Community Health. ;Oak Ridge National Lab., TN. ;Pharmakon Research International, Inc., Waverly, PA.
Malignant neoplasms ;
Hypoxanthine phosphoribosyltransferase ;
Sister chromatid exchange ;
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||Using Chinese hamster ovary (CHO) cells in culture, the authors have defined an assay, CHO/HGPRT, to quantify mutagen-induced cytotoxicity and mutations at the hypoxanthine-guanine phosphoribosyltransferase (hgprt) locus. This assay permits elucidation of the structure-activity relationship and analysis of relative mutagenic potency of various classes of chemical mutagens. By expanding the CHO/HGPRT assay to include chromosome aberration and sister-chromatid exchange (SCE), the authors can analyze the interrelationships of these four distinct biological effects and compare each endpoint for its predictive power of human-level effect. (Copyright (c) 1987 by Hemisphere Publishing Corporation.)
||Pub. in Molecular Toxicology, v1 p217-234 1987. Prepared in cooperation with Texas Univ. Medical Branch at Galveston. Dept. of Preventive Medicine and Community Health, Oak Ridge National Lab., TN., and Pharmakon Research International, Inc., Waverly, PA.
|NTIS Title Notes
||Reprint: Multiple-Endpoint Mutagenesis with Chinese Hamster Ovary (CHO) Cells: Evaluation with Eight Carcinogenic and Non-Carcinogenic Compounds.
|PUB Date Free Form
||57B; 57F; 57Y
||PC A03/MF A01