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RECORD NUMBER: 118 OF 172

OLS Field Name OLS Field Data
Main Title Multiple-Endpoint Mutagenesis with Chinese Hamster Ovary (CHO) Cells: Evaluation with Eight Carcinogenic and Non-Carcinogenic Compounds.
Author Hsie, A. W. ; San Sebastian, J. R. ; Perdue, S. W. ; Schenley, R. L. ; Winters, M. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Texas Univ. Medical Branch at Galveston. Dept. of Preventive Medicine and Community Health. ;Oak Ridge National Lab., TN. ;Pharmakon Research International, Inc., Waverly, PA.
Year Published 1987
Report Number EPA/600/J-87/295;
Stock Number PB88-185137
Additional Subjects Mutagens ; Ovary ; Hamsters ; Chromosomes ; Carcinogens ; Malignant neoplasms ; Reprints ; Cytotoxins ; Hypoxanthine phosphoribosyltransferase ; Sister chromatid exchange ; Carcinoma
Holdings
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Status
NTIS  PB88-185137 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1988
Collation 21p
Abstract Using Chinese hamster ovary (CHO) cells in culture, the authors have defined an assay, CHO/HGPRT, to quantify mutagen-induced cytotoxicity and mutations at the hypoxanthine-guanine phosphoribosyltransferase (hgprt) locus. This assay permits elucidation of the structure-activity relationship and analysis of relative mutagenic potency of various classes of chemical mutagens. By expanding the CHO/HGPRT assay to include chromosome aberration and sister-chromatid exchange (SCE), the authors can analyze the interrelationships of these four distinct biological effects and compare each endpoint for its predictive power of human-level effect. (Copyright (c) 1987 by Hemisphere Publishing Corporation.)
Supplementary Notes Pub. in Molecular Toxicology, v1 p217-234 1987. Prepared in cooperation with Texas Univ. Medical Branch at Galveston. Dept. of Preventive Medicine and Community Health, Oak Ridge National Lab., TN., and Pharmakon Research International, Inc., Waverly, PA.
NTIS Title Notes Journal article.
Title Annotations Reprint: Multiple-Endpoint Mutagenesis with Chinese Hamster Ovary (CHO) Cells: Evaluation with Eight Carcinogenic and Non-Carcinogenic Compounds.
PUB Date Free Form c1987
Category Codes 57B; 57F; 57Y
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 817620524
Origin NTIS
Type CAT