Main Title |
Mutagenic and Clastogenic Properties of 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone: A Potent Bacterial Mutagen in Drinking Water. |
Author |
Meier, J. R. ;
Blazak, W. F. ;
Knohl, R. B. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. Toxicology and Microbiology Div. ;SRI International, Menlo Park, CA. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/340; |
Stock Number |
PB88-202114 |
Additional Subjects |
Furans ;
Chromosomes ;
Potable water ;
Mutagens ;
Pharmacology ;
Water pollution ;
Salmonella typhimurium ;
Cell nucleus ;
Hamsters ;
Mice ;
Rats ;
Ovary ;
Ribosomes ;
Toxicity ;
Bone marrow ;
Drugs ;
Contaminants ;
Reprints ;
Drinking water ;
Chromosome aberrations ;
Microsomes(Liver) ;
Water pollutants(Chemical) ;
Cricetulus ;
Fibroblasts ;
Pollutants
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-202114 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
16p |
Abstract |
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was found to be a direct-acting mutagen in the Ames test for strains TA1535, TA1538, TA92, TA97, TA98, TA100 and TA102. The highest mutagenic response (approximately 13,000 revertants/nmol) was seen in strain TA100. The TA100 response was six- to tenfold higher than in TA98, TA97, and TA102, and 100- to 500-fold higher than in TA1535, TA92, and TA1538. The addition of a 9,000 x g supernatant fraction (S-9) from livers of polychlorinated biphenyl-treated rats, along with cofactors for NADPH generation, resulted in a 90% reduction in the TA100 mutagenicity. MX induced chromosomal aberrations in Chinese hamster ovary cells after 6-8 hr exposure without S-9 at a dose as low as 4 micro/ml, and after 2 hr exposure with S-9 at a dose of 75 micro/ml. The oral dose of MX lethal to 50% (LD50) in Swiss-Webster mice was determined to be 128 mg/kg. MX did not induce micronuclei in mouse bone marrow when administered by oral gavage at doses up to 70% of the LD50. (Copyright (c) 1987 Alan R. Liss, Inc.) |
Supplementary Notes |
Pub. in Environmental and Molecular Mutagenesis, v10 p411-424 1987. Prepared in cooperation with SRI International, Menlo Park, CA. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Mutagenic and Clastogenic Properties of 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone: A Potent Bacterial Mutagen in Drinking Water. |
PUB Date Free Form |
c1987 |
Category Codes |
68D; 57F; 57Q; 57Y |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
819623359 |
Origin |
NTIS |
Type |
CAT |