||Absorption, Distribution, Excretion, and Metabolism of a Single Oral Dose of o-Ethyl o-4-Nitrophenyl Phenylphosphonothioate in Hens.
Abou-Donia, M. B. ;
Reichert, B. L. ;
Ashry, M. A. ;
||Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The disposition and metabolism of a single oral 10 mg/kg (LD50) of uniformly phenyl-labeled (14C)EPN (O-ethyl O-4 nitrophenyl (14C) phenylphosphonothioate) were studied in adult hens. The birds were protected from acute toxicity with atropine sulfate. Three treated hens were killed at each time interval (days): 0.5, 2, 4, 8, 12. Radioactivity was adsorbed from the gastrointestinal tract and distributed in all tissues. Most of the dose was excreted in the combined urinary-fecal excreta (74%). Only traces of the radioactivity (0.2%) were detected in expired CO2. Most of the excreted radioactive materials were identified as phenylphosphonic acid (PPA), O-ethyl phenylphosphonic acid (EPPA), and O-ethyl phenylphosphonothioc acid (EPPTA). Radioactivity in tissues reached a peak of 11.8% in 12 days. The highest concentration of radioactivity was present in the liver followed by bile, kidney, adipose tissue, and muscle. EPN was the major compound identified in brain, spinal cord, sciatic nerve, kidney, and plasma.
||Pub. in Toxicology and Applied Pharmacology 70, p18-28 Mar 83. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Absorption, Distribution, Excretion, and Metabolism of a Single Oral Dose of o-Ethyl o-4-Nitrophenyl Phenylphosphonothioate in Hens.
|PUB Date Free Form
||6T; 6O; 57Y; 57Q
||PC A02/MF A01