Main Title |
Letter from Rhom and Haas Company to US EPA regarding Submission of Abstract and Summary Pages from Draft Epidemiology Study using Chloromethyl Ethers with Attachments. |
CORP Author |
Rohm and Haas Co., Bristol, PA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Publisher |
26 Jul 1990 |
Year Published |
1990 |
Report Number |
FYI-OTS-0790-0776; |
Stock Number |
OTS-0000776 |
Additional Subjects |
Respiratory system diseases ;
Epidemiology ;
Chloromethyl ethers ;
Toxic substances ;
Neoplasms ;
Occupational exposure ;
Lung cancer ;
Diagnosis(Medicine) ;
Carcinogens ;
Induction ;
Dose-response relationships ;
Humans ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS-0000776 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
53p |
Abstract |
Lung cancers occurred at a higher rate among workers who had been potentially exposed in the past to chloromethyl-methyl- ether/bis-chloromethyl-ether than among unexposed workers at the same plant (RR 4.4, 95%Cl 1.8-10.9), or among an externalreference population (RR 4.4, 95%CI 5.5-10). The average age at diagnosis among the exposed was at least 10.5 years lower than among theunexposed. The predominantly small-cell cancers of the exposed were mostly oat-cell, a characteristic of lung cancers in groups exposed to CMME/BCME. There was a positive dose response. The mean time from first exposure to diagnosis was 13 years (95%CI 8-18 years). Dose and induction time were not associated. The rate for the exposed workers peaked somewhere between 7 and 13 years after the start-up of the process, and has declined since. It is impossible to say if the period of excess rate has passed completely, but there are indications that it is essentially over. |
Supplementary Notes |
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Availability Notes |
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Category Codes |
57E; 57Y; 57U; 68G |
NTIS Prices |
PC A05/MF A01 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
035500220 |
Origin |
NTIS |
Type |
CAT |