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RECORD NUMBER: 178 OF 1173

OLS Field Name OLS Field Data
Main Title Chlorobenzene-Impaired Lindane Metabolism and the Effect of Pretreatment with Chlorobenzene, Lindane, or Chlorobenzene Plus Lindane.
Author Chadwick, R. W. ; Copeland, M. F. ; Froehlich, R. ; Cooke, N. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/J-83-208;
Stock Number PB84-205160
Additional Subjects Pesticides ; Toxicology ; Chlorine organic compounds ; Rats ; Laboratory animals ; Dosage ; Reprints ; Lindane ; Cyclohexane/hexachloro ; Chlorobenzene
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB84-205160 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 14p
Abstract The storage and metabolism of lindane (r-HCH) was studied in the female rat after the administration of a hepatotoxic dose of chlorobenzene. Impaired lindane metabolism was observed following a challenge dose of 1.12g chlorobenzene/kg. The data indicated that a hepatotoxic dose of chlorobenzene (CB) selectively impaired certain pathways, such as dehydrochlorination and the direct hydroxylation of lindane, to a greater extent than others, such as the dehydrogenation and dechlorination of lindane. Pretreatment with a subtoxic level of chlorobenzene produced: (1) significant increases in the dehydrogenation of lindane, (2) significant increase in the excretion of metabolites derived from the dehydrogenation of lindane through hexachlorocylohexene, r-HCCH, (4) significant improvement in the excretion of metabolites derived from CB-impaired dehydrochlorination of lindane as well as from the CB-impaired hydroxylation of lindane, and (5) significant reduction in the level of unaltered lindane stored in the adipose tissue.
Supplementary Notes Pub. in Jnl. of Toxicology and Environmental Health, 12 p599-610 1983.
NTIS Title Notes Journal article.
Title Annotations Reprint: Chlorobenzene-Impaired Lindane Metabolism and the Effect of Pretreatment with Chlorobenzene, Lindane, or Chlorobenzene Plus Lindane.
PUB Date Free Form 1983
Category Codes 6T; 57Y; 68E
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 424418142
Origin NTIS
Type CAT