Main Title |
Biochemical Studies of Promoters of Carcinogenesis in Rat Liver. |
Author |
Kitchin, K. T. ;
Brown., J. L. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA/600/J-89/441; |
Stock Number |
PB91-109330 |
Additional Subjects |
Carcinogens ;
Liver ;
Biochemistry ;
Halohydrocarbons ;
Lethal dosage ;
Female ;
Rats ;
Deoxyribonucleic acids ;
Reprints ;
Reference standards ;
DNA damage ;
Ornithine decarboxylase ;
Cytochrome P-450 ;
Alanine aminotransferase
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-109330 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
Adult female rats were orally dosed with 1/5 the LD50 of either an initiator of carcinogens (1,2-dibromo-3-chloropropane (DBCP)), promoters or putative promoters of carcinogenesis (hexachlorobenzene, alpha-hexachlorocyclohexane, kepone and toxaphene) or noncarcinogens (coumaphos, EDTA, caprolactam, 8-hydroxyquinoline, titanium(IV)oxide, sodium diethyldithiocarbamate (DEDTC), and sucrose) at 21 and 4 hours before sacrifice. The initiator and promoters selected in the study were all of the halogenated hydrocarbon class. DBCP caused a large degree of hepatic DNA damage and an increase in hepatic ODC activity. At doses ranging between 1/5 to 3/5 the LD50, all four promoters or putative promoters induced rat hepatic ODC activity. The seven noncarcinogens produced several biochemical effects at doses of 1/5 the LD50: serum alaine aminotransferase (SGPT) increases (caprolactam and DEDTC), decreased hepatic cytochrome P-450 (sucrose and DEDTC) and increased hepatic ODC (8-hydroxyquinoline and DEDTC). None of the seven noncarcinogens caused hepatic DNA damage or coordinate induction of hepatic ODC and cytochrome P-450. |
Supplementary Notes |
Pub. in Teratogenesis, Carcinogenesis, and Mutagenesis, v9 n5 p273-285 Oct 89. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Biochemical Studies of Promoters of Carcinogenesis in Rat Liver. |
Category Codes |
57Y; 57B; 68G |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
036519179 |
Origin |
NTIS |
Type |
CAT |