Main Title |
Factors Associated with Reduced Fertility and Implantation Rates in Females Mated to Acrylamide Treated Rats. |
Author |
Sublet, V. H. ;
Zenick, H. ;
Smith, M. K. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Cincinnati Univ., OH. Dept. of Environmental Health. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA/600/J-89/062; |
Stock Number |
PB90-103680 |
Additional Subjects |
Fertility ;
Toxicity ;
Acrylamide ;
Rats ;
Male ;
Female ;
Reproduction(Biology) ;
Germ cells ;
Dose rate ;
Reprints ;
Animal sex behavior ;
Fertilization ;
Ovum implantation
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-103680 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
17p |
Abstract |
A series of studies was conducted to examine the role of copulatory dysfunction, spermatotoxicity, and/or impaired fertilization in the reduced rates of fertility and implantation observed in females mated to acrylamide-treated male rats. In initial experiments, males were gavaged with 0, 5, 15, 30, 45, or 60 mg/kg acrylamide (ACR) for 5 days and then mated serially to naive females. ACR treatment reduced fertility and increased pre- and post-implantation loss, primarily over the first 3 weeks post-treatment. The data suggest that events critical to the fertilizing ability of the sperm appear to play a major role in the reduced reproductive competence associated with ACR treatment in male rats. (Copyright (c) 1989 Elsevier Scientific Publishers Ireland Ltd.) |
Supplementary Notes |
Pub. in Toxicology, v55 p53-67 Mar 89. Prepared in cooperation with Cincinnati Univ., OH. Dept. of Environmental Health. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Factors Associated with Reduced Fertility and Implantation Rates in Females Mated to Acrylamide Treated Rats. |
Category Codes |
57Y; 68G |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
932617107 |
Origin |
NTIS |
Type |
CAT |