Main Title |
Health assessment document for ethylene oxide / |
Author |
Gray, A. ;
Harris, B. ;
Bosch, S. ;
Santodonato, J. ;
Bayard, S.
|
CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, |
Year Published |
1984 |
Report Number |
EPA-600/ 8-84-009a |
Stock Number |
PB84-209873 |
OCLC Number |
10677649 |
Subjects |
Environmental health ;
Ethylene oxide--Toxicology ;
Carcinogens
|
Additional Subjects |
Ethylene oxide ;
Environmental surveys ;
Toxicology ;
Public health ;
Chemical industry ;
Industrial hygiene ;
Exposure ;
Mutagens ;
Risk ;
Laboratory animals ;
Ecology ;
Industrial wastes ;
Assessments ;
Chemical properties ;
Plants(Botany) ;
Sampling ;
Chemical analysis ;
Malignant neoplasms ;
Bioassay ;
Soils ;
Air pollution ;
Water pollution ;
Animals ;
Dosage ;
Transport properties ;
Utilization ;
Sources ;
Occupational safety and health ;
Cancer ;
Pharmacokinetics ;
Path of pollutants ;
Land pollution
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EHAM |
RA1242.T67 E45 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
EJBD |
EPA 600-8-84-009A |
|
Headquarters Library/Washington,DC |
12/03/2014 |
EKBD |
EPA-600/8-84-009A |
|
Research Triangle Park Library/RTP, NC |
03/19/2004 |
ELBD ARCHIVE |
EPA 600-8-84-009A |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ELBD RPS |
EPA 600-8-84-009A |
repository copy |
AWBERC Library/Cincinnati,OH |
03/26/2019 |
ESAD |
EPA 600-8-84-009A |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
NTIS |
PB84-209873 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Edition |
External review draft. |
Collation |
xvi, various pagings : illustrations ; 28 cm |
Abstract |
The largest single use of ethylene oxide is an intermediate in the synthesis of ethylene glycol. However, small amounts of this epoxide are used as a sterilant or pesticide in commodities, pharmaceuticals, medical devices, tobacco, and other items, representing a considerable potential for human exposure. The pharmacokinetics of ethylene oxide have not been studied extensively. While no studies found in the literature searched concerned the absorption of this chemical, toxicity data suggest that absorption occurs via the respiratory and gastrointestinal tracts. Acute exposure to ethylene oxide in humans results in symptoms of headache, vomiting, dyspnea, and diarrhea. Subacute and chronic effects are not well documented. Data indicate that many different types of genetic damage may be induced following exposure to ethylene oxide. It was found to be mutagenic in the Ames Salmonella assay to Bacillus subtilis and to Drosophilia melanogaster, as well as in cultured mammalian cell and assay systems. The alkylating and mutagenic properties of ethylene oxide are sufficient causes of concern about its potential carcinogenicity. Though there are no definitive, epidemiologic studies, the data are consistent with the animal data in that there seems to be a strong association between an increased risk of cancer, especially leukemia, and prolonged inhalation exposure to ethylene oxide. |
Notes |
Syracuse Research Corporation prepared the chapters on chemical properties, sampling, air quality, and biological effects. "Do not cite or quote." "EPA-600/ 8-84-009a." "April 1984." Includes bibliographical references (pages 10-l-10-27). |
Place Published |
Research Triangle Park, N. Car. |
Corporate Au Added Ent |
Syracuse Research Corporation.; United States. Environmental Protection Agency. Environmental Criteria and Assessment Office. |
PUB Date Free Form |
1984 |
NTIS Prices |
PC A13/MF A01 |
BIB Level |
m |
Medium |
unmediated |
Content |
text |
Cataloging Source |
OCLC/T |
OCLC Time Stamp |
20190325060724 |
Language |
eng |
Origin |
OCLC |
Type |
CAT |
OCLC Rec Leader |
01887cam 2200457Ia 45010 |