Main Title |
Cell-Mediated Mutagenesis, an Approach to Studying Organ Specificity of Chemical Carcinogens. |
Author |
Langenbach, Robert ;
Nesnow, Stephen ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1983 |
Report Number |
EPA-600/D-83-029; |
Stock Number |
PB83-239749 |
Additional Subjects |
Toxicology ;
Cells(Biology) ;
Carcinogens ;
Deoxyribonucleic acids ;
Invitro analysis ;
Responses ;
Chemical compounds ;
Mutagenesis ;
Organ specificity
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB83-239749 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
18p |
Abstract |
A number of approaches have been employed to elucidate the causes of organ and species specificity. In the earlier studies, homogenates of various tissues were used to metabolically activate the chemical; however, metabolite profiles, DNA-adduct profiles, and induced mutagenic responses of cell homogenates differ from those of intact cells. More recent studies have looked at the nature of carcinogen metabolites and DNA-adducts formed in cells or tissues or at the nature and persistence of DNA-adducts in in vivo tissues. Differences in the results from these various approaches are apparent. In addition, the nature and amount of DNA-adducts are only correlated with the biological response expected in the tissue. The ability to measure a biological response from system well as parameters such as chemical metabolism, DNA adducts, DNA repair, etc., would provide a useful system for elucidating some of the biological mechanisms leading to the phenomena of specificity. |
PUB Date Free Form |
Jul 83 |
Category Codes |
6T; 6C; 57Y; 57F |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
324618954 |
Origin |
NTIS |
Type |
CAT |