||Modeling the Accumulation of Three Waterborne Chlorinated Ethanes in Fathead Minnows ('Pimephales promelas'): A Physiologically Based Approach.
Lien, G. J. ;
Nichols, J. W. ;
McKim, J. M. ;
Gallinat, C. A. ;
||Environmental Research Lab.-Duluth, MN. ;AScI Corp., Duluth, MN.
Water pollution effects(Animals) ;
Chlorinated hydrocarbons ;
Chemical models ;
Regional blood flow ;
Pimephales promelas ;
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||A physiologically based kinetic model was used to predict the accumulation of a homologous series of chlorinated ethanes in fathead minnows (Pimephales promelas). Uptake and accumulation of these compounds are described in terms of a few fundamental physiological, morphological, and physicochemical parameters. Chemical residues in 30-d-old fathead minnows exposed to 1,1,2,2-tetrachloroethane, pentachloroethane, and hexachloroethane were used to evaluate model performance. The predicted and observed accumulations of the chlorinated ethanes were in close agreement. A quantitative assessment of the major factors regulating the exchange of these compounds indicates that the cutaneous surface may be an important route of uptake in small fish.
||Pub. in Environmental Toxicology and Chemistry, v13 n7 p1195-1205 1994. Prepared in cooperation with AScI Corp., Duluth, MN.
|NTIS Title Notes
||Reprint: Modeling the Accumulation of Three Waterborne Chlorinated Ethanes in Fathead Minnows ('Pimephales promelas'): A Physiologically Based Approach.
||PC A03/MF A01