Main Title |
Failure to Produce Arsenic Neurotoxicity in the Rat. An Experimental Study. |
Author |
Schaumburg, Herbert H. ;
|
CORP Author |
American Public Health Association, Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1980 |
Report Number |
EPA-560/11-80-022; |
Stock Number |
PB80-209505 |
Additional Subjects |
Toxicology ;
Arsenic ;
Rats ;
Exposure ;
Humans ;
Parenteral infusions ;
Laboratory animals ;
Concentration(Composition) ;
Nervous systems ;
Toxic substances ;
Histopathology ;
Neurotoxins ;
Animal models
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Internet Access |
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB80-209505 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
17p |
Abstract |
Prolonged, low-level exposure to inorganic arsenic can produce peripheral neuropathy in humans, and is a serious industrial health hazard. The clinical expression of arsenic neuropathy is similar to other toxic neuropathies of the dying-back type. No satisfactory animal model of arsenic neuropathy has been devised. Rats underwent weekly intraperitoneal injections with solutions of arsenic trioxide. Strengths of 2mg/kg, 5mg/kg, 10mg/kg and 15mg/kg were used. The 15 mg/kg animals died shortly after receiving the injection. The other animals survived and, after eighteen months, appeared normal. Histopathological study of the peripheral and central nervous systems of these animals was unremarkable. It appears that the rat is not the appropriate species for the study of inorganic arsenic neurotoxicity. |
Supplementary Notes |
Prepared in cooperation with Albert Einstein Coll. of Medicine, Bronx, NY. Inst. of Neurotoxicology. |
NTIS Title Notes |
Final rept.. |
PUB Date Free Form |
May 80 |
Category Codes |
6T; 6E; 57Y; 57O |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
500/00 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323782821 |
Origin |
NTIS |
Type |
CAT |