Main Title |
Comparative Tissue Distribution of Mirex and Chlordecone in Fetal and Neonatal Rats. |
Author |
Kavlock, Robert J. ;
Chernoff, Neil ;
Rogers, Ellen ;
Whitehouse, Douglas ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1980 |
Report Number |
EPA-600/J-80-141; |
Stock Number |
PB81-232068 |
Additional Subjects |
Pesticides ;
Rats ;
Chlorine organic compounds ;
Distribution ;
Tissues(Biology) ;
Placenta ;
Dosage ;
Laboratory animals ;
Insecticides ;
Reprints ;
Mirex ;
Kepone ;
Gestation ;
Lactation ;
Fetuses
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB81-232068 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
The transport of mirex and chlordecone (Kepone) across the placental during late gestation and through the milk during lactation was investigated in the rat. In the placental transport study, doses of 5 mg/kg were administrered on Day 15, 18 or 20 of gestation and animals were killed 4, 24, or 48 hr after treatment. Both compounds crossed the placental and were present in the fetus at all examination times. Maternal tissue levels exceeded fetal tissues. No effects of gestational age at time of treatment or of the fetus in the uterus were seen. In the lactation study, doses of 1 or 10 mg/kg/day were administered on Days 2-5 postpartum and pups were killed at intervals up to 12 days after treatment. The secretion of milk appeared to be a major route of elimination for both pesticides for nursing females, and the greater amount of mirex excreted via the milk as compared with chlordecone is in agreement with differences in their reported octanol-water partition coefficients. Initially, mirex entered the milk more rapidly than chlordecone. After cessation of treatment, mirex milk levels fell quickly, but chlordecone levels remained fairly constant. In the pups, mirex tissue levels paralleled milk levels; chlordecone levels, however, continued to increase in the tissues throughout the observation period. |
Supplementary Notes |
Pub. in Pesticide Biochemistry and Physiology 14, p227-235 1980. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Comparative Tissue Distribution of Mirex and Chlordecone in Fetal and Neonatal Rats. |
PUB Date Free Form |
Aug 80 |
Category Codes |
6T; 6F; 57Y; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323801935 |
Origin |
NTIS |
Type |
CAT |