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Main Title

Toxicological Review of 2-Hexanone (CAS No. 591-78-6). In Support of Summary Information in the Integrated Risk Information System (IRIS).

CORP Author

Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.

Year Published

2009

Report Number

EPA/635/R-09/008F

Stock Number

PB2010-101624

Additional Subjects

Hexanones ; Toxicology ; Health effects ; Risk assessment ; Toxicokinetics ; Absorption ; Distribution ; Pathology ; Neoplasms ; Inhalation ; Ingestion(Biology) ; Bioassay ; Hazardous identification ; Cancer assessments ; Carcinogensis ; Dose-response relationships ; CAS No 591-78-6

Internet Access

Description	Access URL
	https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=P1005DWT.PDF

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB2010-101624	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

136p

Abstract

The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to 2-hexanone. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of 2-hexanone. The intent of Section 6, Major Conclusions in the Characterization of Hazard and Dose Response, is to present the major conclusions reached in the derivation of the reference dose, reference concentration and cancer assessment, where applicable, and to characterize the overall confidence in the quantitative and qualitative aspects of hazard and dose response by addressing the quality of data and related uncertainties. The discussion is intended to convey the limitations of the assessment and to aid and guide the risk assessor in the ensuing steps of the risk assessment process.

Supplementary Notes