| Main Title |
Initial Submission: TSCA Health and Safety Study Cover Sheet with Continuation Sheet re: Preliminary Histopath Evaluation in Subchronic Inhalation Dog Study of Strobilurin (Confidential Information), with Attachment and dated 12/10/99 (Sanitized). |
| CORP Author |
BASF A.G., Ludwigshafen am Rhein (Germany, F.R.).;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
13 Dec 1999 |
| Year Published |
1999 |
| Report Number |
8EHQ-1199-14611S; |
| Stock Number |
OTS-0559858 |
| Additional Subjects |
Toxicity ;
Subchronic inhalation ;
Histopathology ;
Dogs ;
Laboratory animals ;
Pathology ;
Lesions ;
Concentration ;
Males ;
Females ;
Hepatocytomegaly ;
Dosage ;
Glycogen ;
Organs ;
Strobilurin
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0559858 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
A preliminary micropathology evaluation was performed on the following potential target organs from all dogs on study: liver, kidney, pituitary, thyroid, bone marrow and heart. Lesions suggestive of a compound relationship were observed in the liver and kidney. The liver lesion consisted of a hepatocytomegaly and affected the males and females from the 800 and 2500 ppm dose groups (M: 0,0,3,4; F: 0,0,3,4). The hepatocytomegaly was characterized by an enlargement of the hepatocytes resulting in a narrowing of the sinusolds. The hepatocyte cytoplasm was more ground-glass in appearance compared to that of the control dogs, which displayed a slight to moderate background accumulation of glycogen material. The liver lesion was compatible with the clinical pathology findings of liver enzyme induction (all dose groups) and the liver weight increases in the 800 and 2500 ppm male and female dogs. The kidney lesion consisted of a degeneration of the proximal tubular epithelial cells, and was confined to the mid- to deep renal cortices. The location of the affected tubules suggests that the lesion may be confined to the P3 segment of the proximal tubules. The proximal tubular degeneration occurred only in the male dogs and spanned all dose groups (M: 0,1,1,3). As depicted in the attached photographs (Figures 1-4), the renal lesion consisted of a minimal to mild cellular swelling resulting in enlargement of the tubular epithelium, causing the nuclei to be more widely spaced apart. Additionally, the cells were less confluent compared to that of the control animals; the cell shape was more rounded and the cell borders were more distinct. Rarely individual cell necrosis was observed (not shown in the photographs), characterized by shrunken cells with eosinophilic cytoplasm and nuclear pyknosis; these findings lended evidence to the degenerative nature of this lesion. |
| Supplementary Notes |
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| Availability Notes |
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| Category Codes |
57Y; 57O |
| NTIS Prices |
PC A02/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019102330 |
| Origin |
NTIS |
| Type |
CAT |
