| Main Title |
Mutagenicity Evaluation of Xylene with Cover Letter. |
| CORP Author |
Litton Bionetics, Inc., Kensington, MD. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
1 Dec 1982 |
| Year Published |
1982 |
| Report Number |
878210347; |
| Stock Number |
OTS-0205935 |
| Additional Subjects |
Mutagens ;
Xylenes ;
Toxicity ;
Carogenicity tests ;
Genetics ;
Mutation ;
Bacteria ;
Cells(Biology) ;
In vivo analysis ;
Assaying ;
Cytogenetics ;
Lymphoma ;
Cytotoxicity ;
Evaluation ;
American Petroleum Institute
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0205935 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
151p |
| Abstract |
The test chemical, Xylene, was evaluated for its genetic properties in a battery of tests consisting of a test for mitotic gene conversion in yeast, gene mutation tests in bacteria, gene mutation tests in culture mammalian cells and in vivo chromosome analysis in rat bone marrow cells. This series of tests provides a sensitive screen for the detection of substance which produce mutagenic and/or clastogenic alterations. A high percentage of known mammalian mutagens and carcinogens demonstrate activity in one or more of the tests conducted in this evaluation, and positive results in one or more of these tests are an indication that the test substance has mutagenic and/or carcinogenic potential and that further analysis to define the limits of expression of this potential is warranted. Negative results in all of these tests suggest that the test material lack genetic activity but are not sufficient for an unequivocal determination of genetic safety. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57F; 57E; 57Y |
| NTIS Prices |
PC A09/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
009400860 |
| Origin |
NTIS |
| Type |
CAT |
