| Main Title |
Biomarkers of Exposure to Particulate Air Pollution in the Czech Republic. |
| Author |
Lewtas, J. ;
Binkova, B. ;
Miskova, I. ;
Subrt, P. ;
Lenicek, J. ;
|
| CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. National Exposure Research Lab. ;Academy of Sciences, Prague (Czech Republic). Inst. of Experimental Medicine. ;Teplice District Inst. of Hygiene, Prague (Czech Republic). |
| Publisher |
16 Oct 2000 |
| Year Published |
2000 |
| Report Number |
EPA/600/A-01/009; |
| Stock Number |
PB2001-103694 |
| Additional Subjects |
Biological markers ;
Air pollution effects(Humans) ;
Particulates ;
Biological effects ;
Exposure ;
Health outcomes ;
Health effects ;
Polycyclic aromatic hydrocarbons ;
Trace metals ;
Urinary metabolites ;
Biomarkers ;
Czech Republic
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB2001-103694 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
38p |
| Abstract |
The use of biomarkers in the Teplice Program, provided a key tool to relate health outcomes to individual personal exposures and to provide measures of confounding exposures. This research program on the health effects of air pollution studied a population living in the heavily industrialized district of Teplice in Northern Bohemia and compared the exposure and health of this population to that of a non-industrialized district, Prachatice, in Southern Bohemia. The studies included characterization of the environmental and personal air pollution exposure, biomarkers, and studies on reproductive, respiratory, and neurobehavioral effects. Biomarkers were measured in blood, urine, placenta, and sperm. The biomarkers included measures of exposure (e.g., urine metabolites and blood metals), dose (e.g., DNA adducts), DNA damage, genetic and cytogenetic effects, and susceptibility. During winter temperature inversions, unusually high concentrations of a complex mixture of air pollutants were measured, including fine particles, genotoxic organic compounds, and toxic trace elements. This population, however, was also exposed to multiple pollutants via all pathways, and including pollutants resulting from environmental exposures, occupational exposures, and personal habits (e.g., tobacco and alcohol use). Longitudinal and repeated measures used individuals as their own control to examine the influence of environmental exposures as they changed over time and season. |
| Supplementary Notes |
Prepared in cooperation with Academy of Sciences, Prague (Czech Republic). Inst. of Experimental Medicine. and Teplice District Inst. of Hygiene, Prague (Czech Republic). |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Highlights Notes |
%AUT:R. /Sram |
| NTIS Title Notes |
Book chapter, 1992-1999 |
| Category Codes |
68G; 68A; 57U; 57J |
| NTIS Prices |
PC A04/MF A01 |
| Primary Description |
600/09 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028201440 |
| Origin |
NTIS |
| Type |
CAT |
