Main Title |
Subchronic Toxicity Study of Ozonated and Ozonated/Chlorinated Humic Acids in Sprague-Dawley Rats: A Model System for Drinking Water Disinfection. |
Author |
Daniel, F. B. ;
Robinson, M. ;
Ringhand, H. P. ;
Stober, J. A. ;
Page, N. P. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Page Associates, Gaithersburg, MD. ;Pathology Associates, Inc., West Chester, OH. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-92/124; |
Stock Number |
PB92-164946 |
Additional Subjects |
Potable water ;
Toxicity ;
Ozone ;
Chlorine ;
Disinfection ;
Rats ;
Body weight ;
Organ weight ;
Carbon ;
Humic acids ;
Food consumption ;
Water consumption ;
Tests ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-164946 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
Male and female Sprague-Dawley rats were administered drinking water containing humic acids either non-disinfected or following ozonation (O3) or ozonation/chlorination (O3/CL2) for 90 consecutive days. Test animals drank either of two concentrations of humic acids, 0.25 and 1.0g/L total organic carbon (TOC), while controls received phosphate-buffered, distilled water. No consistent significant treatment-related effects were observed in body weight gain, organ weights, food or water consumption, or hematological and clinical chemistry parameters. No target organs were identified from the histopathological examination of the tissues. The most significant observation, an increase in liver to body weight ratio for the male animals in the 1.0g/LO3/CL2 humic acid group, was not observed in any other group, nor was it corroborated via any biochemical measurements or histopathological analysis. (Copyright (a) 1990 American Chemical Society.) |
Supplementary Notes |
Pub. in Environmental Science and Technology, v25 n1 p93-98 Jan 91. See also PB87-145629. Prepared in cooperation with Page Associates, Gaithersburg, MD., and Pathology Associates, Inc., West Chester, OH. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Subchronic Toxicity Study of Ozonated and Ozonated/Chlorinated Humic Acids in Sprague-Dawley Rats: A Model System for Drinking Water Disinfection. |
Category Codes |
57Y; 57U; 50B; 68G; 68D |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
214321526 |
Origin |
NTIS |
Type |
CAT |