||Deposition Patterns of Cigarette Smoke in Human Airways.
Martonen., T. B. ;
||Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;North Carolina Univ. at Chapel Hill. Div. of Pulmonary Diseases.
Air pollution effects(Humans) ;
Mathematical models ;
Respiratory function tests ;
Pulmonary neoplasms ;
Bronchial neoplasms ;
||Some EPA libraries have a fiche copy filed under the call number shown.
||Experimental deposition patterns of cigarette smoke in surrogate human airway systems are very heterogeneous. Particle deposits are enhanced at predictable, well-defined morphological regions; most specifically, carinal ridges within bifurcation zones and along posterior sections of tubular airways. The efficiency of the mucociliary transport mechanism in vivo is also reduced at airway branchings. The geometrical sites of preferential particle deposition and impaired clearance can be correlated with clinically observed anatomical sites exhibiting increased incidences of bronchogenic carcinomas. These locations are not compatible with current theoretical models simulating only the usual particle deposition processes of inertial impaction, sedimentation, and diffusion, while intending to account for particle hygroscopicity. Moreover, data from human subject exposures indicate that heretofore unknown factors affect the distribution of inhaled cigarette smoke. A new mathematical model is presented that explains cigarette smoke deposition patterns, including bifurcation 'hot spots,' in terms of composition and cumulative density. (Copyright (c) 1992, American Industrial Hygiene Association.)
||Pub. in Jnl. of American Industrial Hygiene Association, v53 n1 p6-18 Jan 92. See also PB88-224282 and PB89-130454. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Div. of Pulmonary Diseases.
|NTIS Title Notes
||Reprint: Deposition Patterns of Cigarette Smoke in Human Airways.
||PC A03/MF A01