| Main Title |
Modeling the Accumulation of Three Waterborne Chlorinated Ethanes in Fathead Minnows ('Pimephales promelas'): A Physiologically Based Approach. |
| Author |
Lien, G. J. ;
Nichols, J. W. ;
McKim, J. M. ;
Gallinat, C. A. ;
|
| CORP Author |
Environmental Research Lab.-Duluth, MN. ;AScI Corp., Duluth, MN. |
| Publisher |
c1994 |
| Year Published |
1994 |
| Report Number |
EPA/600/J-94/354; |
| Stock Number |
PB94-210416 |
| Additional Subjects |
Water pollution effects(Animals) ;
Chlorinated hydrocarbons ;
Ethane ;
Pharmacokinetics ;
Chemical models ;
Regional blood flow ;
Skin(Anatomy) ;
Physiology ;
Reprints ;
Pimephales promelas ;
Minnows ;
Ethane/1-1-2-2-tetrachloro ;
Ethane/pentachloro ;
Ethane/hexachloro
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-210416 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
A physiologically based kinetic model was used to predict the accumulation of a homologous series of chlorinated ethanes in fathead minnows (Pimephales promelas). Uptake and accumulation of these compounds are described in terms of a few fundamental physiological, morphological, and physicochemical parameters. Chemical residues in 30-d-old fathead minnows exposed to 1,1,2,2-tetrachloroethane, pentachloroethane, and hexachloroethane were used to evaluate model performance. The predicted and observed accumulations of the chlorinated ethanes were in close agreement. A quantitative assessment of the major factors regulating the exchange of these compounds indicates that the cutaneous surface may be an important route of uptake in small fish. |
| Supplementary Notes |
Pub. in Environmental Toxicology and Chemistry, v13 n7 p1195-1205 1994. Prepared in cooperation with AScI Corp., Duluth, MN. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Modeling the Accumulation of Three Waterborne Chlorinated Ethanes in Fathead Minnows ('Pimephales promelas'): A Physiologically Based Approach. |
| Category Codes |
68D; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
428724473 |
| Origin |
NTIS |
| Type |
CAT |
