Main Title |
Potentiation of 2,6-Dinitrotoluene Genotoxicity in Fischer 344 Rats by Pretreatment with Pentachlorophenol. |
Author |
Chadwick, R. W. ;
George, S. E. ;
Chang, J. ;
Kohan, M. J. ;
Dekker, J. P. ;
|
CORP Author |
Environmental Protection Agency, Research Triangle Park, NC.;Air Force Office of Scientific Research, Bolling AFB, DC. |
Publisher |
1991 |
Year Published |
1991 |
Report Number |
AFOSR-ISSA-90-0029; 2312; A4; AFOSR-TR-91-0433 ; |
Stock Number |
AD-A235 140/1 |
Additional Subjects |
Animals ;
Chlorine ;
Enteric bacteria ;
Germicides ;
Intestines ;
Liver ;
Metabolites ;
Mutagens ;
Organic compounds ;
Peanut oil ;
Pesticides ;
Urine ;
Vehicles ;
Organochlorine insecticides ;
Dinitrotoluenes ;
Pentachlorophenol ;
Carcinogens ;
Mixed function oxidases ;
Mutagens
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
AD-A235 140/1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
The organochlorine pesticide, pentachlorophenol, a potent sulfotransferase inhibitor, reportedly reduces the binding of 2,6-dinitrotoluene, an industrial hepatocarcinogen to hepatic DNA by 95% after a single i.p. injection. Activation of 2,6-dinitrotoluene to genotoxic metabolites involves enzymes in both the liver and the intestinal flora. Since pentachlorophenol also has bactericidal activity and induces hepatic mixed function oxidase activity after longer treatment, the effect of pentachlorophenol on intestinal enzyme activity and the biotransformation of 2,6-dinitrotoluene to genotoxic metabolites was studied after 1, 2, 4, and 5 weeks of treatment. Male Fischer 344 rats were dosed daily, by gavage, with either 20 mg/kg pentachlorophenol or the peanut oil vehicle. After 1, 2, 4, and 5 weeks, select control and treated animals were injected p.o. with 75 mg/kg 2,6-dinitrotoluene and transferred to metabolism cages, where urine was collected for 24 hr and tested for mutagenic activity by the Ames Salmonella typhimurium reversion assay. |
Availability Notes |
Availability: Pub. in Pesticide Biochemistry and Physiology, v39 p168-181 1991. Available only to DTIC users. No copies furnished by NTIS. |
Title Annotations |
Reprint: Potentiation o 2,6-Dinitrotoluene Genotoxicity in Fischer 344 Rats by Pretreatment with Pentachlorophenol. |
Category Codes |
68E; 57Y; 57F |
NTIS Prices |
PC A03/MF A01 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
122105890 |
Origin |
NTIS |
Type |
CAT |