| Main Title |
Assessment of Ambient UFP Health Effects: Linking Sources to Exposure and Responses in Extrapulmonary Organs. |
| Author |
G. Oberdorster ;
A. Elder ;
J. Finkelstein ;
M. Frampton ;
P. Hopke
|
| CORP Author |
Rochester Univ., NY.; Clarkson Univ., Potsdam, NY.; GSF - Forschungszentrum fuer Umwelt und Gesundheit G.m.b.H., Neuherberg (Germany).; California Univ., San Diego.; LMU - Ludwig-Maximilians-Universitat, Munchen (Germany).; Environmental Protection Agency, Washington, DC. |
| Year Published |
2011 |
| Report Number |
EPA R827354 |
| Stock Number |
PB2013-100299 |
| Additional Subjects |
Particulates ;
Health effects ;
Exposure ;
Respiratory system ;
Age ;
Air pollution ;
Atherosclerotic disease ;
Cardiovascular system ;
Diabetes ;
Diseases ;
Endothelium ;
Organs ;
Oxidation ;
Pollution sources ;
Stresses ;
Translocation ;
Vascular system ;
Ultrafine particles(UFP)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB2013-100299 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
35p |
| Abstract |
In summary, our studies show that ambient PM can have significant oxidative capacity, that UFP can induce significant effects not only in the respiratory tract but more importantly affect the vascular and cardiac system and that age and underlying disease (susceptibility factors) are critical modifying factors. Furthermore, our demonstration of their efficient translocation from deposition sites in the respiratory tract to other organs such as heart and CNS provides plausibility for UFP-induced oxidative stress in those organs. Such translocation could be particularly detrimental in susceptible individuals with dysfunctional vascular endothelium as the earliest manifestation of atherosclerotic vascular disease, such as seen in type 2 diabetes. This is presently being tested in ongoing studies. |
| Supplementary Notes |
Prepared in cooperation with Clarkson Univ., Potsdam, NY., GSF - Forschungszentrum fuer Umwelt und Gesundheit G.m.b.H., Neuherberg (Germany)., California Univ., San Diego. and LMU - Ludwig-Maximilians-Universitat, Munchen (Germany). Sponsored by Environmental Protection Agency, Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5301 Shawnee Road, Alexandria, VA, 22312, USA. |
| PUB Date Free Form |
Dec 2011 |
| Category Codes |
68A; 57E; 57W |
| NTIS Prices |
PC A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
120300740 |
| Origin |
NTIS |
| Type |
CAT |
