Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effect of insecticides on benzo(a)pyrene carcinogenesis /
Author Triolo, Anthony J.
CORP Author Jefferson Medical Coll., Philadelphia, PA.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1978
Report Number EPA/600/1-78/066; EPA-R-803486
Stock Number PB-290 322
Subjects Insecticides--Physiological effect.
Additional Subjects Insecticides ; Pesticides ; Toxicology ; Aromatic polycyclic hydrocarbons ; Activity ; Phosphorus organic compounds ; Mice ; Females ; Laboratory animals ; Experimental data ; Diets ; Ingestion(Biology) ; Neoplasms ; Lung ; Enzymes ; Tissues(Biology) ; Chlorine organic compounds ; Stomach ; Hydroxylases ; Carcinogenesis ; Parathion ; Toxaphene ; Camphenes ; Carbaryl ; Carbamic acid/methyl-(naphthyl-ester) ; Benzopyrene ; Oncogenesis ; Phosphorothiotic acid/O-O-(dimethyl-ester)-O-(nitrophenyl-ester)
Library Call Number Additional Info Location Last
NTIS  PB-290 322 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation vi, 32 pages ; 28 cm.
The pesticides parathion, toxaphene, and carbaryl were tested for their ability to induce tumors in the forestomach and lungs of female Ha/ICR and A/J mice respectively. None of these pesticides, when fed alone in the diet of the mice, showed significant oncogenic activity. On the other hand, toxaphene enhanced benzo(a)pyrene (BP)-induced tumors and increased BP hydroxylase activity in the forestomach of the Ha/ICR mice and carbaryl enhanced BP-induced tumors and increased BP hydroxylase activity in the lungs of the A/J mice. In each instance, it is possible that toxaphene and carbaryl exhibited a cooncogenic effect in enhancing the BP-induced tumors. Conversely, toxaphene decreased the incidence of BP-induced tumors and inhibited BP hydroxylase activity in the lungs of the A/J mice. These results suggest that increased BP hydroxylase activity in tissues tends to enhance tumor formation and a decrease in the enzyme activity may have a protective effect agains tumors. The relationship between enzyme inducibility and tumor formation may be due to the level of oncogenic epoxides formed in target organs. Further, studies of the formation of specific oncogenic epoxides of BP in tissues after treatment with these pesticides would help towards defining more clearly the relationship between BP hydroxylase inducibility and BP oncogenesis.
"EPA-600/1-78-066." Includes bibliographical references (pages 28-31). Microfiche.