Record Display for the EPA National Library Catalog
RECORD NUMBER: 48 OF 175
|OLS Field Name||OLS Field Data|
|Main Title||Effect of insecticides on benzo(a)pyrene carcinogenesis /|
|Author||Triolo, Anthony J.|
|CORP Author||Jefferson Medical Coll., Philadelphia, PA.;Health Effects Research Lab., Research Triangle Park, NC.|
|Publisher||U.S. Environmental Protection Agency, Health Effects Research Laboratory,|
|Report Number||EPA/600/1-78/066; EPA-R-803486|
|Stock Number||PB-290 322|
|Additional Subjects||Insecticides ; Pesticides ; Toxicology ; Aromatic polycyclic hydrocarbons ; Activity ; Phosphorus organic compounds ; Mice ; Females ; Laboratory animals ; Experimental data ; Diets ; Ingestion(Biology) ; Neoplasms ; Lung ; Enzymes ; Tissues(Biology) ; Chlorine organic compounds ; Stomach ; Hydroxylases ; Carcinogenesis ; Parathion ; Toxaphene ; Camphenes ; Carbaryl ; Carbamic acid/methyl-(naphthyl-ester) ; Benzopyrene ; Oncogenesis ; Phosphorothiotic acid/O-O-(dimethyl-ester)-O-(nitrophenyl-ester)|
|Collation||vi, 32 pages ; 28 cm.|
The pesticides parathion, toxaphene, and carbaryl were tested for their ability to induce tumors in the forestomach and lungs of female Ha/ICR and A/J mice respectively. None of these pesticides, when fed alone in the diet of the mice, showed significant oncogenic activity. On the other hand, toxaphene enhanced benzo(a)pyrene (BP)-induced tumors and increased BP hydroxylase activity in the forestomach of the Ha/ICR mice and carbaryl enhanced BP-induced tumors and increased BP hydroxylase activity in the lungs of the A/J mice. In each instance, it is possible that toxaphene and carbaryl exhibited a cooncogenic effect in enhancing the BP-induced tumors. Conversely, toxaphene decreased the incidence of BP-induced tumors and inhibited BP hydroxylase activity in the lungs of the A/J mice. These results suggest that increased BP hydroxylase activity in tissues tends to enhance tumor formation and a decrease in the enzyme activity may have a protective effect agains tumors. The relationship between enzyme inducibility and tumor formation may be due to the level of oncogenic epoxides formed in target organs. Further, studies of the formation of specific oncogenic epoxides of BP in tissues after treatment with these pesticides would help towards defining more clearly the relationship between BP hydroxylase inducibility and BP oncogenesis.
"EPA-600/1-78-066." Includes bibliographical references (pages 28-31). Microfiche.