Record Display for the EPA National Library Catalog

RECORD NUMBER: 314 OF 1145

OLS Field Name OLS Field Data
Main Title Determining effect of pollutants on the immune system /
Author Zarkower, A. ; Davis, J. ; Ferguson, F. ; Strickler, D.
Other Authors
Author Title of a Work
Zarkower, A.
CORP Author Pennsylvania State Univ., University Park.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1981
Report Number EPA/600/1-81/020; EPA-68-02-2472
Stock Number PB81-171829
Subjects Immune response. ; Fly ash--Physiological effect. ; Air--Pollution--Physiological effect.
Additional Subjects Fly ash ; Immunologic diseases ; Inhalation ; Neoplasms ; Exposure ; Escherichia coli ; Mice ; Laboratory animals ; Antigens ; Aerosols ; Lymphocytes ; Immune responses ; Infections ; Air pollution effects(Animals)
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB81-171829 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 95 pages ; 28 cm
Abstract
The purpose of this project was to determine the effects of fly-ash inhalation on the ability of animals to resist infections, neoplastic growth, and the development of hypersensitive responses. Mice were exposed to fly ash from two different sources, carbon black, and filtered ambient air only. Following exposures of various lengths (days to months), a variety of tests were done to determine the immunologic competence of lymphocytes, neutrophiles, and macrophages. Fly ash had a suppressive effect on the ability of mice to respond to Escherichia coli antigens given by aerosol; this suppression was much less severe than that following exposures to carbon black. Fly ash had little effect on the ability of B and T lymphocytes to respond to mitogens and to be stimulated for cytolytic response against tumor cells. The cellular response of BCG-sensitized mice to purified protein derivative of tuberculin was enhanced. The effect of fly ash on macrophages was more pronounced, involving decreased phagocytic activity, decreased antibody-dependent cytolosis, increased cytoxic activity against tumor cells, and decreased ability to activate T cell mitogenesis.
Notes
Caption title. "March 1981." "EPA-600/1-81-020." Microfiche.