Record Display for the EPA National Library Catalog
RECORD NUMBER: 1328 OF 1519
|OLS Field Name||OLS Field Data|
|Main Title||Studies on the Percutaneous Absorption of Parathion and Paraoxon. II. Distribution of 32P-Labelled Parathion within the Skin.|
|Author||Fredriksson., Torsten ;|
|CORP Author||Communicable Disease Center, Atlanta, Ga.|
|Stock Number||PB-280 573; PB-280 565|
|Additional Subjects||Absorption(Biology) ; Pesticides ; Insecticides ; Skin(Anatomy) ; Phosphorus organic compounds ; Distribution ; Labeled substances ; Autoradiography ; Experimental data ; Humans ; Laboratory animals ; Exposure ; Temperature ; Reprints ; Parathion ; Phosphoric acid/(diethyl-ester)-(nitrophenyl-ester) ; Toxic substances ; Pesticide residues ; Bioaccumulation|
The distribution of 32P-labelled parathion (E605, or diethyl 4-nitrophenyl thiononophosphate) within the skin following topical application for various periods of time was studied in excised skin from man, rat, rabbit, and cat. Two different approaches were chosen: (1a) determination of radioactivity in 25 consecutive cellulose tape strips from the surface of human skin, (1b) autoradiography of the same strips; and (2) autoradiography of skin sections with the use of four different techniques. Various factors influencing the autoradiograms were studied, special attention being paid to artefacts due to diffusion, type of radiation, and exposure time of the photosensitive material. It was found that parathion penetrates into hair follicles and sebaceous glands to some extent, but it was concluded that this is not necessarily the main route of absorption. There also was increasing activity below the epidermal layers, and transepidermal absorption is as likely. The results were discussed with special attention to the interpretation of the autoradiograms and to the implications for other studies of the percutaneous absorption of parathion.
Included in PB-280 565, Journal articles on toxicology. Group 12.