Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Assessment of Teratogenic Potential of Trichlorofon in Mice and Rats (Journal Version).
Author Courtney, K. D. ; Andrews, J. E. ; Springer, J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Food and Drug Administration, Washington, DC. Center for Food Safety and Applied Nutrition.
Publisher 1986
Year Published 1986
Report Number EPA/600/J-86/498;
Stock Number PB89-130421
Additional Subjects Insecticides ; Pesticides ; Toxicity ; Teratogens ; Laboratory animals ; Concentration(Composition) ; Exposure ; Lethal dosage ; Phosphorus organic compounds ; Reprints ; Trichlorofon ; Phosphoric acid/trichloro-hydroxyethyl-(dimethyl ester)
Library Call Number Additional Info Location Last
NTIS  PB89-130421 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 24p
Trichlorofon was evaluated for its teratogenic potential in the CD-1 mouse at doses of 200, 300, or 400 mg/kg/day administered by gavage on days 7-16 of gestation. In the CD-1 mouse, TCF was teratogenic, fetotoxic and lethal at the two highest dose levels which were also maternally lethal. At the lowest dose level which was not maternally lethal, there was a significant decrease in the number of calcified centers in the forepaws and hindpaws indicating fetotoxicity and a delay in maturation. TCF was administered at doses of 50, 100, or 200 mg/kg/day to CD rats by gavage on gestational days 7-19 (study I) or 8-20 (study II). In both study I and II, the highest dose level was maternally lethal. In study I, TCF was teratogenic with a shift in rib profile. In study II, TCF was teratogenic with an increased incidence in malformations of the urinary system. Additionally, TCF was fetotoxic with reduced ossification of the skulls.