Record Display for the EPA National Library Catalog

RECORD NUMBER: 120 OF 1538

OLS Field Name OLS Field Data
Main Title Assessment of Teratogenic Potential of Trichlorofon in Mice and Rats (Journal Version).
Author Courtney, K. D. ; Andrews, J. E. ; Springer, J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Food and Drug Administration, Washington, DC. Center for Food Safety and Applied Nutrition.
Publisher 1986
Year Published 1986
Report Number EPA/600/J-86/498;
Stock Number PB89-130421
Additional Subjects Insecticides ; Pesticides ; Toxicity ; Teratogens ; Laboratory animals ; Concentration(Composition) ; Exposure ; Lethal dosage ; Phosphorus organic compounds ; Reprints ; Trichlorofon ; Phosphoric acid/trichloro-hydroxyethyl-(dimethyl ester)
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB89-130421 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 24p
Abstract
Trichlorofon was evaluated for its teratogenic potential in the CD-1 mouse at doses of 200, 300, or 400 mg/kg/day administered by gavage on days 7-16 of gestation. In the CD-1 mouse, TCF was teratogenic, fetotoxic and lethal at the two highest dose levels which were also maternally lethal. At the lowest dose level which was not maternally lethal, there was a significant decrease in the number of calcified centers in the forepaws and hindpaws indicating fetotoxicity and a delay in maturation. TCF was administered at doses of 50, 100, or 200 mg/kg/day to CD rats by gavage on gestational days 7-19 (study I) or 8-20 (study II). In both study I and II, the highest dose level was maternally lethal. In study I, TCF was teratogenic with a shift in rib profile. In study II, TCF was teratogenic with an increased incidence in malformations of the urinary system. Additionally, TCF was fetotoxic with reduced ossification of the skulls.