||Effect of Methyl Oleate Hydroperoxide, a Possible Toxic Ozone Intermediate, on Human Normal and Glucose-6-Phosphate Dehydrogenase-Deficient Erythrocytes.
Williams, P. ;
Calabrese, E. J. ;
Moore, G. S. ;
||Massachusetts Univ., Amherst. Dept. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC.
Blood cells ;
Oleic acid/hydroperoxyl-methyl ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Erythrocytes of both normal and glucose 6-phosphate dehydrogenase (G-6-PD)-deficient humans responded in a dose-dependent manner to the oxidant stress of methyl oleate hydroperoxide (MOHP) as measured by decreases in G-6-PD activity, increases in methemoglobin (METHB) levels, and decreases in reduced glutathione (GSH). The G-6-PD-deficient erythrocytes displayed a markedly enhanced sensitivity to MOHP-induced decreases in G-6-PD activity and METHB increases while being less sensitive than normal erythrocytes to changes in GSH levels.