Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Evaluation of the Dorset Sheep as a Predictive Animal Model for the Response of G-6-PD Deficient Human Erythrocytes to a Proposed Systemic Toxic Ozone Intermediate, Methyl Linoleate Hydroperoxide.
Author Williams, P. S. ; Calabrese, E. J. ; Moore, G. S. ;
CORP Author Massachusetts Univ., Amherst. Dept. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-R-805797; EPA/600/J-83/273;
Stock Number PB85-173201
Additional Subjects Ozone ; Toxicology ; Erythrocytes ; Humans ; Sheep ; Blood cells ; Reprints ; Dehydrogenase/glucose-phosphate ; Animal models ; Glutathiones
Library Call Number Additional Info Location Last
NTIS  PB85-173201 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 20p
Erythrocytes of both G-6-PD deficient humans and Dorset sheep, an animal model with an erythrocyte G-6-PD deficiency, both responded in a dose-dependent manner to the oxidant stress of MLHP as measured by decreases in G-6-PD activity, increases in METHB levels and decreases in GSH. However, the human G-6-PD deficient erythrocytes were considerably more sensitive to the formation of METHB than the sheep erythrocytes while the reverse was the case for GSH parameter. The results suggest a qualitative difference in the response of sheep erythrocytes and human G-6-PD deficient erythrocytes to MLHP that seriously questions the value of the sheep erythrocyte as a quantitatively accurate predictive model. (Copyright (c) 1983 by Marcel Dekker, Inc.)