Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Biochemical Changes in Humans upon Exposure to Sulfuric Acid Aerosol and Exercise.
Author Chaney, Suzanne ; Blomquist, Wendy ; Muller, Keith ; Goldstein, George ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-600/J-80-400;
Stock Number PB83-153726
Additional Subjects Sulfuric acid ; Toxicology ; Aerosols ; Humans ; Exercise(Physiology) ; Exposure ; Reprints ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB83-153726 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 8p
This study evaluated the effect of a single exposure to sulfuric acid aerosol on six human biochemical blood parameters. A total of 18 human subjects were exposed to ambient air for 4 hr on the first day of exposure and to 100 micrograms/cu. m. (0.033 micro M) sulfuric acid aerosol (0.5 micrometers mean mass diameter) for 4 hr on the second day. A total of 17 human subjects were exposed for 4 hr to ambient air on both exposure days. On each exposure day, at 30 min and 90 min after exposure was initiated, all subjects engaged in a 15-min exercise period (walking 4 mph on atreadmill inclined at 10 degrees). Six biochemical blood parameters were measured before and after exposure: glutathione, lysozyme, glutatione reductase, serum glutamic exaloacetic acid transaminase, serum vitamin E, and 2,3-diphosphoglyceric acid. The results indicate no significant effect of one 4-hr exposure of humans to 100 micrograms/cu. m. sulfuric acid aerosol. One significant post-exposure effect did occur--an increase in glutathione reductase--for both the control and acid-exposured group. It is concluded that at the levels studied, sulfuric acid aerosol is neutralized in the upper airways; consequently, no cellular damage is measurable.