||Commercial Hexane Metabolism and Pharmacokinetics (Progress Report) with Cover Letter dated 07/15/91.
||Research Triangle Inst., Durham, NC. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||19 Jul 1991
Chemical compounds ;
In vivo analysis ;
Environmental exposure pathway ;
Research program ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
This is the second in a series of reports on the progress achieved in the research program on Commercial Hexane (CH) Metabolism and Pharmacokinetics being conducted at RTI. This research is being conducted to fulfill the requirements of the final test rule on CH issued by the EPA. During the period since the initiation of this project studies have been conducted on the design, development and validation of the specific devices and experimental approaches to be used for the studies included in this research program. In vivo pilot absorption, distribution, metabolism and excretion (ADME) studies have been successfully completed at inhalation exposure concentrations of 900 and 9000 ppm. The results of these studies support initiation of the definitive in vivo ADME studies.