||Genetic activity profiles and hazard assessment /
Waters, Michael D. ;
STack, H. F. ;
Brady, A. L.
||Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
|| U.S. Environmental Protection Agency : Office of Research and Development, Health Effects Research Laboratory,
Computer systems programs ;
Organic compounds ;
Risk assessment ;
Mutagenicity tests ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||27 pages ; 28 cm
A methodology has been developed to display and evaluate multiple test quantitative information on genetic toxicants for purposes of hazard/risk assessment. Dose information is collected from the open literature: either the lowest effective dose (LED) or the highest ineffective dose (HID) tested is recorded for each agent and bioassay system. For each agent in the data base, the quantitative results from genetic and related test systems are represented by computer-generated bar graphs 'genetic activity profiles'. The x-axis unit values correspond to approximately 200 different test systems. Bioassay systems are organized according to classes of genetic activity and subdivided by the phylogenetic level of the test organism. The y-axis values are the logarithmically transformed LED or HID values. Genetic activity profiles were prepared which illustrate a quantitative data base on the genetic and related effects of nearly 200 chemicals for which some data are available on carcinogenicity in humans. The information may be used for purposes of comparative chemical hazard assessment. Together with information derived from animal cancer tests and human epidemiological studies, assessments may be made regarding potential human health risks associated with exposure to chemical substances.