||Mathematical Modeling of Ozone Absorption in the Lower Respiratory Tract.
Overton, J. ;
Graham, R. C. ;
Miller, F. J. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Respiratory systems ;
Mathematical models ;
Air pollution ;
Chemical reactions ;
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A mathematical O3 dosimetry model has been developed for simulating the local absorption of O3 in the lower respiratory tract (LRT) of animals and man. The model takes into account LRT anatomy, transport in the lumen and air spaces, transport and chemical reactions in the liquid layers and in the underlying tissue and capillaries. Differential equations are used to describe the processes of transport and chemical reactions; solutions are obtained numerically. Simulations are illustrated with results of two investigations: the effect of anatomical models on predicted LRT uptake of O3 in rat and guinea pig, and the effect of exercise on the uptake and distribution of ozone in the LRT of man.