Main Title |
Relationship between Tumorigenic Potency, Ki-ras Codon 12 Mutations, and DNA Adducts Induced by Cyclopenta(cd)pyrene. |
Author |
Nesnow, S. ;
Ross, J. A. ;
Nelson, G. ;
Wilson, K. ;
Roop, B. C. ;
|
CORP Author |
Medical Coll. of Ohio at Toledo. Dept. of Pathology. ;Ohio State Univ., Columbus. Dept. of Preventive Medicine. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering. ;Integrated Lab. Systems, Research Triangle Park, NC.;Environmental Protection Agency, Research Triangle Park, NC. Carcinogenesis and Metabolism Branch. |
Publisher |
c1994 |
Year Published |
1994 |
Report Number |
EPA-R-816069; EPA/600/J-94/551; |
Stock Number |
PB95-148128 |
Additional Subjects |
Carcinogens ;
Codon ;
Mutation ;
DNA adducts ;
Ras genes ;
Pulmonary neoplasms ;
Dose-response relationships ;
Metabolic activation ;
Pharmacokinetics ;
Adenoma ;
Mice ;
Animal disease models ;
Reprints ;
Cyclopenta(cd)pyrene
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB95-148128 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Cyclopenta(cd)pyrene (CPP) was examined for its lung tumorigenic activity in strain A/J mice, for the formation and persistence of CPP-induced DNA adducts in lung tissue, and for its induction of mutations in the Ki-ras oncogene from CPP-induced turmors. CPP displayed high tumorigenic activity, including 97.7 lung adenomas/mouse at 200 mg/kg. Ki-ras codon 12 mutations in the DNA of induced tumors were: GGT --> CGT (50%); GGT --> GTT (15%); GGT --> TGT (25%); GGT --> GAT (10%). All DNA adducts in the lungs of CPP-treated mice were CPP-3,4-oxide derived and most were CPP-3,4-oxide-2'-deoxyguanosine adducts. CPP is highly tumorigenic in the strain A/J mouse lung adenoma model, being 5 times more active than benzo(a)pyrene. The increased activity of CPP may be related to the unique induction of the GGT --> CGT, Ki-ras codon 12 mutation. (Copyright (c) 1994 Gordon and Breach Science Publishers S.A.) |