||Effects of Ammonium Sulfate Aerosol Exposure on Lung Structure of Normal and Elastase-Impaired Rats and Guinea Pigs.
Busch, R. H. ;
Buschbom, R. L. ;
Cannon, W. C. ;
Lauhala, K. E. ;
Miller, F. J. ;
||Battelle Pacific Northwest Labs., Richland, WA.;Health Effects Research Lab., Research Triangle Park, NC.
Guinea pigs ;
Laboratory animals ;
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Rats and guinea pigs, pretreated with intratracheally administered elastase or saline, were exposed to 1.03 mg/cu. m.(NH4)2SO4. Identically treated controls were sham exposed. Measurements and evaluation of structural changes were conducted using morphometric techniques on SEM photographs and by applying subjective ratings. Pathology studies were conducted by light and electron microscopy. All examination methods confirmed elastase-induced emphysema, which was aggravated by (NH4)2SO4 exposure in the rat. Ammonium sulfate exposure of saline-treated animals produced measurable degrees of enlargement of alveoli, and alveolar ducts and sacs.