Approximately 150 deaths a year in the United States are attributable to pesticide poisoning, with total morbidity reaching up to 100 times that number. Several sophisticated methods of analyzing biological samples for pesticides and their metabolic products have been developed in recent years. However, knowledge of the existence of these methods, of the sampling techniques required, and of the location of laboratories where the analyses may be performed has not been made generally available to the physician. The purpose of this communication is to bridge this gap so that the practicing physician can derive the most meaningful information from the analytical chemist.