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Main Title Pulmonary function and bronchial reactivity in human subjects with exposure to ozone and respirable sulfuric acid aerosol an environmental chamber study / {microform} :
Author Kulle, Thomas J. ; Kerr, H. David ; Farrell, Bernard P. ; Sauder, Larry R. ; Swift, David L.
Other Authors
Author Title of a Work
Kulle, Thomas J.
CORP Author Maryland Univ., Baltimore. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1982
Report Number EPA/600/1-82/012; EPA-R-803804
Stock Number PB82-255126
Subjects Pulmonary function tests ; Bronchi ; Aerosols
Additional Subjects Ozone ; Sulfuric acid ; Bronchi ; Respiratory system ; Toxicology ; Exposure ; Air pollution ; Humans ; Aerosols ; Smoking ; Air pollution effects(Humans) ; Cigarette smoking
Library Call Number Additional Info Location Last
NTIS  PB82-255126 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 44 p. ; 28 cm.
A three-year research study was conducted investigating the effects of individual and sequential exposures to ozone and sulfuric acid aerosol on pulmonary function and bronchial reactivity in human subjects. PHASE I: In healthy smokers and nonsmokers exposed for 4 hours to 98 micrograms/cu. m 0.14 micrometers H2SO4 aerosol, no significant changes in pulmonary function (FVC, FEV1, FEV3, SGaw, FRC, SBNER, Phase IV, CL stat, CL dyn, RL) were observed with exposure or 24 hours post-exposure. PHASE II: The effect of 0.3 ppm O3 on a subsequent exposure to 100 micrograms/cu. m, 0.13 micrometers H2SO4 aerosol was studied in nonsmoking subjects to determine if pre-exposure to O3 would sensitize these individuals to H2SO4 aerosol. Two-hour O3 and 4-hour H2SO4 exposures were empolyed. Pulmonary function (FVC, FEV1, FEV3, SGaw, FRC) and bronchial reactivity to methacholine were measured following single and sequential exposures. No significant changes in pulmonary function were observed with the exposures. No significant increase in bronchial reactivity occurred with any exposure, although a nearly significant decrease resulted following the single H2SO4 exposure. The authors conclude no decrement in function occurs with exposure to respirable H2SO4 aerosol individually or when preceded by O.3 ppm O3.
Caption title. "July 1982." "EPA-600/1-82-012." Microform.