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Main Title Developmental neurotoxicology of polychlorinated biphenyls and related compounds /
Author Tilson, Hugh A. ; Harry, G. J.
Other Authors
Author Title of a Work
Harry, G. Jean.
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1992
Report Number EPA/600/A-92/154
Stock Number PB92-206549
Additional Subjects Polychlorobiphenyl compounds ; Toxicology ; Nervous system ; Teratogenic compounds ; Animals ; Humans ; Health hazards ; Environmental pollutants ; Maternal-fetal exchange ; Psychomotor performance
Library Call Number Additional Info Location Last
NTIS  PB92-206549 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 36 pages ; 28 cm
Polychlorinated biphenyls are stable, lipophilic industrial compounds that are present in residue levels in human tissue, wildlife and freshwater sediment. They are toxic and are known to pass the placenta and intoxicate the fetus. Two large outbreaks of poisoning have occurred in Asia and women pregnant at or after the exposures had children who were developmentally impaired. Laboratory experiments in rhesus monkeys and rodents designed to assess neural or developmental neurotoxic effects show altered activity levels, impaired learning, and delayed ontogeny of reflexes. Children exposed transplacentally to PCBs in North America have been reported to display hypotonia and hyporeflexia at birth, delay in psychomotor development at 6 and 12 months of age and poorer visual recognition at 7 months. PCBs appear to be developmental neurotoxicants in both humans and animals and may pose a significant health risk, particularly to pregnant women and their offspring.