Record Display for the EPA National Library Catalog


Main Title Effects of 2,4-Dithiobiuret on Sensory and Motor Function.
Author Crofton, K. M. ; Dean, K. F. ; Hamrick, R. C. ; Boyes., W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northrop Services, Inc., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/088;
Stock Number PB91-200220
Additional Subjects Toxicology ; Psychomotor performance ; Motor activity ; Sensory thresholds ; Dose-response relationships ; Visual cortex ; Body weight ; Visual evoked potentials ; Startle reaction ; Heat ; Rats ; Reprints ; Dithiobiuret
Library Call Number Additional Info Location Last
NTIS  PB91-200220 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
2,4-Dithiobiuret (DTB) exposure causes a delayed onset muscle weakness in rats that has been attributed to depressed neuromuscular transmission. The present study compares the effects of DTB on both sensory and motor function in rats. Adult male Long-Evans hooded rats were exposed to saline, 0.25, 0.5, or 1.0 mg/kg/day DTB, ip, for 5 consecutive days (Days 1-5). Body weights were monitored throughout the experiment. Motor activity was measured for 1 hr in figure-eight mazes on Days 0, 6, 13, and 27. Forelimb and hindlimb grip strength were assessed on Days 6, 13, and 27. Auditory thresholds were determined for 5- and 40-kHz tones using reflex modification of the startle response on Days 0, 7, 14, and 28. Visual function was examined on Day 6 in animals exposed at 0.5 mg/kg/day using flash- and pattern-elicited visual evoked potentials (FEPs and PEPs, respectively). Thermal sensitivity was measured using the hot plate procedure. All motor endpoints were decreased in a dosage- and time-dependent manner; the higher the dosage the longer the effects lasted. There were no effects on any measure of sensory function with the exception of peak N2 of the FEP. Both the amplitude and latency of FEP N2 were altered by DTB exposure. Decreases in body weight were maximal on Day 9 at 1.0 mg/kg/day (20% from control), but recovered by Day 22. (Copyright (c) 1991 by the Society of Toxicology.)