Research was conducted to determine the most effective techniques or methods for cleanup and decontamination of various wood, metal, and concrete surfaces following spillage of 45% emulsifiable parathion. This involved certain absorbents and chemicals, some of which are readily available in most areas and includes some of those more commonly used or suggested for cleanup and decontamination of parathion spills. Dry soil, attaclay, anhydrous filler, and sawdust were evaluated as absorbent materials used for initial pickup and prevention of spread of contaminated areas. Results of tests indicated that quick containment and absorption of pesticide spillage by such materials to prevent deep penetration into surfaces is very important because after deep penetration the pesticide has a tendency to move to the surface for some time after treatment even though decontamination procedures are thought to be successful in cleaning at the time. It was concluded that physical cleanup of a spillage is the most important procedure within the short time usually required for cleanup of a parathion spill, and more important than realiance upon degradation by use of suggested or recommended materials such as sodium hydroxide, sodium hypochlorite, or other degrading chemicals.