The report gives results of a study that focused on the investigation of fluorinated derivatives of propane and butane to determine if synthesis routes of such compounds were feasible and economical, and to measure the physical properties needed to evaluate the compounds as alternatives to stratospheric ozone depleters that are to be phased out of production by developed countries in a step-wise progression over the period 1996 to 2030. This work resulted in the investigation of 25 compounds including 15 hydrofluorocarbons (HFCs), 9 hydrochlorofluorocarbons (HCFCs) and 1 hydrofluoroether (HFE). Several of the compounds studied had not been previously synthesized and, for many of those which had been reported in the literature, this study resulted in improved synthesis methods. This study, in addition to the synthesis effort, resulted in a sizeable body of thermophysical property data for each chemical.