Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Exocrine Pancreatic Neoplasms Induced by Methylazoxymethanol Acetate in the Guppy 'Poecilia reticulata'.
Author Fournie, J. W. ; Hawkins, W. E. ; Overstreet, R. M. ; Walker, W. W. ;
CORP Author Environmental Research Lab., Gulf Breeze, FL. ;Gulf Coast Research Lab., Ocean Springs, MS.;National Cancer Inst., Bethesda, MD. Div. of Cancer Etiology.;Army Medical Research and Development Command, Washington, DC.
Year Published 1987
Report Number EPA/600/J-87/309; N01-CP-2-6008;
Stock Number PB88-196266
Additional Subjects Organic compounds ; Pancreatic neoplasms ; Fresh water fishes ; Water pollution ; Carcinogens ; Exposure ; Histology ; Sampling ; Malignant neoplasms ; Humans ; Laboratory animals ; Adenoma ; Adenocarcinomas ; Cells(Biology) ; Tests ; Cytoplasm ; Photomicrographs ; Reprints ; Methylazoxymethanol acetate ; MAM-Ac ; Poecilla reticulata ; Guppy
Library Call Number Additional Info Location Last
NTIS  PB88-196266 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1988
Collation 13p
Exocrine pancreatic neoplasms developed in the guppy Poecillia reticulata following a single brief exposure to methylazoxymethanol acetate. Fish 6-10 days old were exposed to concentrations of MAM-Ac up to 100 mg/liter for 2 hours. Exposed specimens were transferred to carcinogen-free water and sampled periodically for tumor development. Pancreatic neoplasms occurred in approximately 9% of histologically examined individuals exposed to 10 mg MAM-Ac/liter or less. Neoplastic lesions were not found in 122 control specimens. The neoplasms included 6 cases diagnosed as adenoma, 7 cases diagnosed as acinar cell carcinoma, and 2 cases diagnosed as adenocarcinoma. The findings of carcinogen-induced pancreatic neoplasms in guppies further strengthen the usefulness of small fish species in carcinogen testing.