Record Display for the EPA National Library Catalog


Main Title Biomarkers of Exposure to Particulate Air Pollution in the Czech Republic.
Author Lewtas, J. ; Binkova, B. ; Miskova, I. ; Subrt, P. ; Lenicek, J. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. National Exposure Research Lab. ;Academy of Sciences, Prague (Czech Republic). Inst. of Experimental Medicine. ;Teplice District Inst. of Hygiene, Prague (Czech Republic).
Publisher 16 Oct 2000
Year Published 2000
Report Number EPA/600/A-01/009;
Stock Number PB2001-103694
Additional Subjects Biological markers ; Air pollution effects(Humans) ; Particulates ; Biological effects ; Exposure ; Health outcomes ; Health effects ; Polycyclic aromatic hydrocarbons ; Trace metals ; Urinary metabolites ; Biomarkers ; Czech Republic
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB2001-103694 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 38p
The use of biomarkers in the Teplice Program, provided a key tool to relate health outcomes to individual personal exposures and to provide measures of confounding exposures. This research program on the health effects of air pollution studied a population living in the heavily industrialized district of Teplice in Northern Bohemia and compared the exposure and health of this population to that of a non-industrialized district, Prachatice, in Southern Bohemia. The studies included characterization of the environmental and personal air pollution exposure, biomarkers, and studies on reproductive, respiratory, and neurobehavioral effects. Biomarkers were measured in blood, urine, placenta, and sperm. The biomarkers included measures of exposure (e.g., urine metabolites and blood metals), dose (e.g., DNA adducts), DNA damage, genetic and cytogenetic effects, and susceptibility. During winter temperature inversions, unusually high concentrations of a complex mixture of air pollutants were measured, including fine particles, genotoxic organic compounds, and toxic trace elements. This population, however, was also exposed to multiple pollutants via all pathways, and including pollutants resulting from environmental exposures, occupational exposures, and personal habits (e.g., tobacco and alcohol use). Longitudinal and repeated measures used individuals as their own control to examine the influence of environmental exposures as they changed over time and season.