||Study of industrial data on candidate chemicals for testing.
Allport, Jeffrey ;
Casey, Sharon ;
Cook, Janet ;
Hall, Peter ;
Helmes., C. Tucker
||SRI International, Menlo Park, Calif.;Environmental Protection Agency, Washington, D.C. Office of Toxic Substances.
||United States, Environmental Protection Agency, Office of Toxic Substances,
||EPA-560/5-77-006; RESEARCH REQUEST-1; EPA-68-01-4109
Chemical industry ;
Organic compounds ;
Environmental surveys ;
Industrial wastes ;
Public health ;
Azo compounds ;
Phosphoric acid ;
Halogen organic compounds ;
Peroxy organic compounds ;
Nitroso compounds ;
||Research Triangle Park Library/RTP, NC
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||1 v. (various pagings) : ill. ; 28 cm.
This report summarizes the work done under Research Request No. 1 and includes three major parts: (1) Data previously collected on an NSF study was supplemented to provide the following information where available on 667 industrial chemicals: (a) U.S. production; (b) estimates of quantities released annually to the environment; (c) major uses; and (d) references on mutagenicity tests. Mutagenicity data on 25 chemicals were evaluated after developing a list of assays and criteria for classifying the results as either positive or negative/inadequate. (2) Tables were prepared which contain economic information on 1791 chemicals belonging to 26 structural classes considered to represent potential industrial carcinogens and mutagens. For those chemicals with annual production greater than one million pounds, market forecasts were prepared which present a brief summary of production, consumption patterns, major uses, possible substitutes, and growth trends. (3) Carcinogenicity data for all chemicals belonging to three classes (epoxides, alkyl halides, and vinyl halides) were used to correlate structural features with carcinogenic activity. Criteria were developed for estimating the potential carcinogenicity of chemicals in each class. These criteria were applied to those chemicals in each class known to be produced commercially or for which there was evidence of significant human exposure. The results of the study were summarized in three separate reports. (Portions of this document are not fully legible)
Project Officer: James Darr. "August 1977." "Research Request No. 1"--t.p. "EPA-560/5-77-006." SRI International