Record Display for the EPA National Library Catalog


Main Title Acute toxicity testing criteria for chemical substances /
Author Normandy, Mary Janet. ; Reynolds, Robert
Other Authors
Author Title of a Work
Reynolds, Robert
Kamely, Daphne.
CORP Author Enviro Control, Inc., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher Premanufacturing Review Division, Office of Toxic Substances, U.S. Environmental Protection Agency ; Available from NTIS,
Year Published 1979
Report Number EPA-560/13-79-009
Stock Number PB80-111073
OCLC Number 08421133
Subjects Toxicology--Testing
Additional Subjects Toxicology ; Chemical compounds ; Bioassay ; Data collection ; Tests ; Criteria ; Procedures ; Lethal dosage ; Mortality ; Inhalation ; Ingestion(Biology) ; Recommendations ; Risk ; Laboratory animals ; Experimental data ; Skin(Anatomy) ; Eye(Anatomy) ; Exposure ; Toxic substances
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJED  EPA-560/13-79-009 OCSPP Chemical Library/Washington,DC 07/30/1999
ELBD ARCHIVE EPA 560-13-79-009 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB80-111073 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation v, 36 p. ; 28 cm.
The report addresses the rationale, considerations, and limitations of acute toxicity testing. General procedures are described for acute tests including lethality studies in oral, dermal, and inhalation toxicity, and irritation studies in dermal and eye toxicity, phototoxicity and skin sensitization. Recommendations are given for the acute toxicity tests which may be used to evaluate the risks associated with the manufacture and processing of chemical substances. Suggested minimum protocols are offered including the choice of test animals, dosage levels, laboratory practices, animal diets, and necropsy requirements. A method is suggested for interpreting the results of these tests and extrapolating to some guidelines for a safety factor in human exposure.
"EPA-560/13-79-009." "PB80-111073." "July 1979." Performing organization Enviro Control, Incorporated. Includes bibliographical references.