| Main Title |
Acute toxicity testing criteria for chemical substances / |
| Author |
Normandy, Mary Janet. ;
Reynolds, Robert
|
| Other Authors |
|
| CORP Author |
Enviro Control, Inc., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
Premanufacturing Review Division, Office of Toxic Substances, U.S. Environmental Protection Agency ; Available from NTIS, |
| Year Published |
1979 |
| Report Number |
EPA-560/13-79-009 |
| Stock Number |
PB80-111073 |
| OCLC Number |
08421133 |
| Subjects |
Toxicology--Testing
|
| Additional Subjects |
Toxicology ;
Chemical compounds ;
Bioassay ;
Data collection ;
Tests ;
Criteria ;
Procedures ;
Lethal dosage ;
Mortality ;
Inhalation ;
Ingestion(Biology) ;
Recommendations ;
Risk ;
Laboratory animals ;
Experimental data ;
Skin(Anatomy) ;
Eye(Anatomy) ;
Exposure ;
Toxic substances
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJED |
EPA-560/13-79-009 |
|
OCSPP Chemical Library/Washington,DC |
07/30/1999 |
| ELBD ARCHIVE |
EPA 560-13-79-009 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| NTIS |
PB80-111073 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
v, 36 p. ; 28 cm. |
| Abstract |
The report addresses the rationale, considerations, and limitations of acute toxicity testing. General procedures are described for acute tests including lethality studies in oral, dermal, and inhalation toxicity, and irritation studies in dermal and eye toxicity, phototoxicity and skin sensitization. Recommendations are given for the acute toxicity tests which may be used to evaluate the risks associated with the manufacture and processing of chemical substances. Suggested minimum protocols are offered including the choice of test animals, dosage levels, laboratory practices, animal diets, and necropsy requirements. A method is suggested for interpreting the results of these tests and extrapolating to some guidelines for a safety factor in human exposure. |
| Notes |
"EPA-560/13-79-009." "PB80-111073." "July 1979." Performing organization Enviro Control, Incorporated. Includes bibliographical references. |
